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dc.contributor.advisorMankin, Alexanderen_US
dc.contributor.authorGupta, Pulkiten_US
dc.date.accessioned2014-02-24T19:00:16Z
dc.date.available2016-02-25T10:30:10Z
dc.date.created2013-12en_US
dc.date.issued2014-02-24
dc.date.submitted2013-12en_US
dc.identifier.urihttp://hdl.handle.net/10027/11304
dc.description.abstractThe goal of this work was to investigate how the interplay of the nascent peptide with the small molecule cofactors modulates ribosome function and as a consequence regulate gene expression in a cell. To study this we used regulatory peptides preceding erythromycin resistance methyltransferase (erm) genes as the model nascent peptides and macrolide antibiotics as model small molecule cofactors. Our studies expanded the general understanding of the mechanisms of functional interactions between the nascent peptide and the ribosomal tunnel, provided new insights into mechanisms of action of NPET-targeting antibiotics, illuminated new aspects of regulation of the resistance mechanisms and provided novel venues for future use of the discovered principles for practical purposes. We believe that unraveling the molecular networks of modulation of ribosomal function by nascent peptides in combination with small molecule cofactors is critical for understanding the basic principles of the regulatory circuitry of the cell.en_US
dc.language.isoenen_US
dc.rightsen_US
dc.rightsCopyright 2013 Pulkit Guptaen_US
dc.subjectTranslationen_US
dc.subjectResistanceen_US
dc.subjectFrameshiftingen_US
dc.subjectMacrolideen_US
dc.subjectKetolideen_US
dc.subjectRibosomeen_US
dc.titleNascent Peptide and Small Molecule Mediated Translation Regulationen_US
thesis.degree.departmentMedicinal Chemistry and Pharmacognosyen_US
thesis.degree.disciplinePharmacognosyen_US
thesis.degree.grantorUniversity of Illinois at Chicagoen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhD, Doctor of Philosophyen_US
dc.type.genrethesisen_US
dc.contributor.committeeMemberVazquez-Laslop, Noraen_US
dc.contributor.committeeMemberKay, Brianen_US
dc.contributor.committeeMemberHo, Yee-Kinen_US
dc.contributor.committeeMemberSimonovic, Miljanen_US
dc.contributor.committeeMemberFederle, Michael J.en_US
dc.type.materialtexten_US


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