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Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice
(Public Library of Science, 2013-02)
Obesity and type 2 diabetes are associated with increased production of Galectin-3 (Gal-3), a protein that modulates inflammation and clearance of glucose adducts. We used Lean and Diet-induced Obese (DIO) WT and Gal-3 KO ...
Rosiglitazone Improves Survival and Hastens Recovery from Pancreatic Inflammation in Obese Mice
(Public Library of Science, 2012-07)
Obesity increases severity of acute pancreatitis (AP) by unclear mechanisms. We investigated the effect of the PPAR-gamma
agonist rosiglitazone (RGZ, 0.01% in the diet) on severity of AP induced by administration of IL-12+ ...
Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice
(Elsevier, 2011-12)
Obesity is associated with chronic inflammation and elevated levels of IL-6. The role of IL-6 in induction of acute-phase proteins and modulation of haematological responses has been demonstrated in models of inflammation ...
Increased Adiposity in Annexin A1-Deficient Mice
(PLoS One, 2013-12)
Production of Annexin A1 (ANXA1), a protein that mediates the anti-inflammatory action of glucocorticoids, is altered in obesity, but its role in modulation of adiposity has not yet been investigated. The objective of this ...