Browsing Pharmacy, College of by Title
Now showing items 83-102 of 181
-
LC-MS-MS analysis of brodifacoum isomers in rat tissue
(Oxford University Press, 2016-05)Brodifacoum (BDF) is a second-generation anticoagulant rodenticide structurally related to warfarin but containing two chiral centers. Highly stable, BDF can contaminate food and water supplies causing accidental poisoning ... -
Let-7 micro RNAs and opioid tolerance
(Frontiers Research Foundation, 2012-06-21)This chapter will focus on the role of microRNAs (miRs) in regulating the actions of opioid drugs through the opioid receptors. Opioids, such as morphine, are analgesics that are used for treating many forms of acute and ... -
Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation
(Elsevier, 2010-08)We propose a numerical framework that permits an effective Atlas-like representation of Chemico-Biological Space (CBS) based on a series of Cartesian planes mapping the ligands with the corresponding targets connected by ... -
Listen carefully: The risk of error in spoken medication orders
(Elsevier, 2010-05)Clinicians and patients often confuse drug names that sound alike (Hicks, Becker, & Cousins, 2008). We conducted auditory perception experiments to assess the impact of similarity, familiarity, background noise and other ... -
Litsea Species as Potential Antiviral Plant Sources
(World Scientific Publishing, 2016-04)Litsea verticillata Hance (Lauraceae), a Chinese medicine used to treat swelling caused by injury or by snake bites, was the first plant identified by our National Institutes of Health (NIH)-funded International Cooperative ... -
Measuring Hospital Efficiency with Data Envelopment Analysis: Nonsubstitutable vs. Substitutable Inputs and Outputs
(Springer Verlag, 2009-12-15)There is a conflict between Data Envelopment Analysis (DEA) theory’s requirement that inputs (outputs) be substitutable, and the ubiquitous use of nonsubstitutable inputs and outputs in DEA applications to hospitals. This ... -
The mechanisms of action of ribosome-targeting peptide antibiotics
(Fronters Media, 2018-05-14)The ribosome is one of the major targets in the cell for clinically used antibiotics. However, the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our current arsenal of ribosome-targeting ... -
Medication therapy management clinic: perception of healthcare professionals in a University medical center setting
(Centro de Investigaciones y Publicaciones Farmaceuticas, 2013)OBJECTIVE: To determine the overall perception and utilization of the pharmacist managed medication therapy management (MTM) clinic services, by healthcare professionals in a large, urban, university medical care setting. ... -
Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E-2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.
(Hindawi Publishing Corporation, 2016)The effect of Menoprogen (MPG) on ovarian granulosa cell (GC) apoptosis was investigated in vitro and in vivo in an aged rat model of menopause. Intragastric administration of Menoprogen or estradiol valerate to 14-month-old ... -
Mentor-Mentee Relationships
(Barnes and Ellis, 2014) -
Meropenem-RPX7009 Concentrations in Plasma, Epithelial Lining Fluid, and Alveolar Macrophages of Healthy Adult Subjects.
(American Society for Microbiology, 2015-12)The steady-state concentrations of meropenem and the β-lactamase inhibitor RPX7009 in plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations were obtained in 25 healthy, nonsmoking adult subjects. ... -
Microbiological Assessment of Polymyxin B Components Tested Alone and in Combination.
(American Society for Microbiology, 2015-12)We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter ... -
Microfluidic devices to enrich and isolate circulating tumor cells.
(Royal Society of Chemistry, 2015-12-21)Given the potential clinical impact of circulating tumor cells (CTCs) in blood as a clinical biomarker for the diagnosis and prognosis of various cancers, a myriad of detection methods for CTCs have been recently introduced. ... -
Minimal Prolongation of Prothrombin Time with Extended Exposure to Argatroban.
(Wiley, 2015-07)In the setting of acute heparin-induced thrombocytopenia (HIT), argatroban is one of the initial anticoagulants of choice, which is eventually bridged to warfarin over a period of 5 or more days. Argatroban prolongs ... -
The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer.
(MDPI, 2015-07-24)The role of microRNAs (miRNAs or miRs) in the pathology of epithelial ovarian cancer (EOC) has been extensively studied. Many miRNAs differentially expressed in EOC as compared to normal controls have been identified, ... -
A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease.
(BioMed Central, 2016-04-29)BACKGROUND: Clinical failures singularly targeting amyloid-β pathology indicate a critical need for alternative Alzheimer's disease (AD) therapeutic strategies. The mixed pathology reported in a large population of AD ... -
Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.
(American Society for Microbiology, 2015-11)Drug resistance is a major problem in Mycobacterium tuberculosis control, and it is critical to identify novel drug targets and new antimycobacterial compounds. We have previously identified an imidazo[1,2-a]pyridine-4- ... -
Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent.
(American Society for Microbiology, 2015-11)Drug resistance is a major problem in Mycobacterium tuberculosis control, and it is critical to identify novel drug targets and new antimycobacterial compounds. We have previously identified an imidazo[1,2-a]pyridine-4-c ... -
Nascent Peptide in the Ribosome Exit Tunnel Affects Functional Properties of the A-site of the Peptidyl Transferase Center
(Elsevier (Cell Press), 2011-02-04)The ability to monitor the nascent peptide structure and to respond functionally to specific nascent peptide sequences is a fundamental property of the ribosome. An extreme manifestation of such response is nascent ... -
National trends in prescription drug expenditures and projections for 2017
(American Society of Health-Systems Pharmacy, 2017-08)Purpose. Historical trends and factors likely to influence future pharmaceutical expenditures are discussed, and projections are made for drug spending in 2017 in nonfederal hospitals, clinics, and overall (all sectors). ...