Now showing items 115-134 of 181

    • Pathway analysis of genome-wide data improves warfarin dose prediction 

      Daneshjou, Roxana; Tatonetti, Nicholas P; Karczewski, Konrad J; Sagreiya, Hersh; Bourgeois, Stephane; Drozda, Katarzyna; Burmester, James K; Tsunoda, Tatsuhiko; Nakamura, Yusuke; Kubo, Michiaki; Tector, Matthew; Limdi, Nita A; Cavallari, Larisa H; Perera, Minoli; Johnson, Julie A; Klein, Teri E; Altman, Russ B (BioMed Central, 2013-05)
      Background: Many genome-wide association studies focus on associating single loci with target phenotypes. However, in the setting of rare variation, accumulating sufficient samples to assess these associations can ...
    • Patient and physician preferences for attributes of coronary revascularization 

      da Silva Magliano, Carlos A.; Monteiro, Andrea L.; Tura, Bernardo Rangel; Oliveira, Claudia Silvia Rocha; de Oliveira Rebelo, Amanda Rebeca; de Aguiar Pereira, Claudia Cristina (Dove Medical Press, 2018-03-23)
      Background: Patients with a diagnosis of coronary artery disease (CAD) may face important decisions regarding treatment options, with the “right choice” depending on the relative weights of risks and benefits. Studies ...
    • Patient Experience-based Value Sets: Are They Stable? 

      Pickard, AS; Hung, YT; Lin, FJ; Lee, TA (Lippincott Williams and Wilkins, 2017)
      Background: Although societal preference weights are desirable to inform resource-allocation decision-making, patient experienced health state-based value sets can be useful for clinical decision-making, but context may ...
    • Pharmacoeconomic implications of thromboprophylaxis with new oral anticoagulants after total hip or knee replacement in the United States 

      Nutescu, Edith (Informa Healthcare, 2013-03)
      Introduction: Adequate thromboprophylaxis after total hip or knee replacement (THR or TKR) is essential to reduce the incidence of venous thromboembolism (VTE) and its associated complications. Although effective, traditional ...
    • Pharmacogenomics: application to the management of cardiovascular disease 

      Johnson, Julie A.; Cavallari, Larisa H.; Beitelshees, Amber L.; Lewis, Joshua P.; Shuldiner, Alan R; Roden, Dan M. (Nature Publishing Group, 2011-09)
      There have been substantial advances in cardiovascular pharmacogenomics in the past decade. Genetic determinants of response to clopidogrel and warfarin have been defined, resulting in changes to the product label for ...
    • Pharmacokinetics of ceftaroline in normal body weight and obese (classes I, II, and III) healthy adult subjects. 

      Justo, JA; Mayer, SM; Pai, MP; Soriano, MM; Danziger, LH; Novak, RM; Rodvold KA, KA (American Society for Microbiology, 2015-07)
      The pharmacokinetic profile of ceftaroline has not been well characterized in obese adults. The purpose of this study was to evaluate the pharmacokinetics of ceftaroline in 32 healthy adult volunteers aged 18 to 50 years ...
    • Pharmacologic Considerations in the Management of Patients Receiving Left Ventricular Percutaneous Mechanical Circulatory Support 

      Allender, J. Erin; Reed, Brent N.; Foster, Jenna L.; Mortez, Jeremy D.; Oliphant, Carrie S.; Jennings, Douglas L.; DiDomenico, Robert J.; Coons, James C. (Wiley, 2017-09-19)
      Percutaneous mechanical circulatory support (MCS) devices, including the intra-aortic balloon pump, Impella, and TandemHeart, are often used for hemodynamic support in the setting of refractory cardiogenic shock. The ...
    • Phenolic Compounds from Eurycorymbus cavaleriei 

      Hea, Yi; Zhang, Li; Zhao, Ming; Tsai, Sam-Hip; Zong, Yuying; Che, Chun-Tao (Taylor & Francis, 2011-06)
      Three new phenolic compounds, eurycorymboside A (1), eurycorymboside B (6), and eurycorymbic acid (8) were isolated from the stem part of Eurycorymbus cavaleriei (Sapindaceae), along with five known phenolic compounds, ...
    • Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis 

      Villaflores, Oliver B.; Macabeo, Allan Patrick G.; Gehle, Dietmar; Krohn, Karsten; Franzblau, Scott G.; Aguinaldo, Alicia M. (Medknow Publications, 2010-10-20)
      Alpinia purpurata or red ginger was studied for its phytochemical constituents as part of our growing interest on Philippine Zingiberaceae plants that may exhibit antimycobacterial activity. The hexane and dichloromethane ...
    • PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients 

      Tonetti, Debra A.; Gao, Weihua; Escarzaga, Diana; Walters, Kelly; Szafran, April; Coon, John S. (SAGE-Hindawi Access to Research, 2012)
      Although the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage ...
    • PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα. 

      Hu, X; Huang, F; Szymusiak, M; Tian, X; Liu, Y; Wang, ZJ (Public Library of Science, 2016-01-08)
      Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain. Effective treatment for OIH is lacking. In this study, we examined the efficacy and ...
    • Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer 

      Li, Gongbo; Thomas, Stacey; Johnson, Jeremy J. (Frontiers, 2013-06)
      The mangosteen (Garcinia mangostana) is a tropical fruit native to Southeast Asia and has long been reported to contain multiple health promoting properties. This fruit is an abundant source of xanthones, a class of ...
    • Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer 

      Petiwala, Sakina M.; Puthenveetil, Angela G.; Johnson, Jeremy J. (Frontiers Research Foundation, 2013-03)
      The Mediterranean diet is rich in fruits and vegetables and has been associated with a variety of health benefits including cancer prevention. One aspect of the diet that has not received enough attention is Mediterranean ...
    • Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer 

      Petiwala, Sakina M.; Puthenveetil, Angela G.; Johnson, Jeremy J. (Frontiers Research Foundation, 2013-03)
      The Mediterranean diet is rich in fruits and vegetables and has been associated with a variety of health benefits including cancer prevention. One aspect of the diet that has not received enough attention is Mediterranean ...
    • Potential Chemopreventive Activity of a New Macrolide Antibiotic from a Marine-Derived Micromonospora sp. 

      Carlson, Skylar; Marler, Laura; Nam, Sang-Jip; Santarsiero, Bernard D.; Pezzuto, John M.; Murphy, Brian T. (MDPI, 2013-04)
      Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity. As part of a program to discover novel phase II enzyme-inducing ...
    • Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators 

      Jain, AD; Potteti, H.; Richardson, BG; Kingsley, L.; Luciano, JP; Ryuzoji, AF; Lee, H.; Krunic, A.; Mesecar A, AD; Reddy, SP; Moore, TW (Elsevier Inc., 2015-10-20)
      Activation of the transcription factor Nrf2 has been posited to be a promising therapeutic strategy in a number of inflammatory and oxidative stress diseases due to its regulation of detoxifying enzymes. In this work, we ...
    • Probing The Structural Requirements of Non-electrophilic Naphthalene-Based Nrf2 Activators. 

      Jain AD; Potteti H; Richardson BG; Kingsley L; Luciano JP; Ryuzoji AF; Lee H; Krunic A; Mesecar AD; Reddy SP; Moore TW (Elsevier Masson, 2015-10-20)
      Activation of the transcription factor Nrf2 has been posited to be a promising therapeutic strategy in a number of inflammatory and oxidative stress diseases due to its regulation of detoxifying enzymes. In this work, we ...
    • Progress in MicroRNA Delivery 

      Zhang, Yu; Wang, Zaijie; Gemeinhart, Richard A. (Elsevier Inc., 2013-09)
      MicroRNAs (miRNAs) are non-coding endogenous RNAs that direct post-transcriptional regulation of gene expression by several mechanisms. Activity is primarily through binding to the 3' untranslated regions (UTRs) of messenger ...
    • Proteolytically activated anti-bacterial hydrogel microspheres 

      Buhrman, Jason S.; Cook, Laura C.; Rayahin, Jamie E.; Federle, Michael J.; Gemeinhart, Richard A. (Elsevier, 2013-11)
      Hydrogels are finding increased clinical utility as advances continue to exploit their favorable material properties. Hydrogels can be adapted for many applications, including surface coatings and drug delivery. Anti-infectious ...
    • Protostane and Fusidane Triterpenes: A Mini-Review 

      Zhao, Ming; Gödecke, Tanja; Gunn, Jordan; Duan, Jin-Ao; Che, Chun-Tao (MDPI, 2013-04)
      Protostane triterpenes belong to a group of tetracyclic triterpene that exhibit unique structural characteristics. Their natural distribution is primarily limited to the genus Alisma of the Alismataceae family, but they ...