Now showing items 1-2 of 2

    • Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism 

      Liu, Yong; Jeong, Hyun-Young; Takahashi, Harumi; Drozda, Katarzyna; Patel, Shitalben R.; Shapiro, Nancy L.; Nutescu, Edith A.; Cavallari, Larisa H. (Nature Publishing Group, 2012-04)
      The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a ...
    • Pathway analysis of genome-wide data improves warfarin dose prediction 

      Daneshjou, Roxana; Tatonetti, Nicholas P; Karczewski, Konrad J; Sagreiya, Hersh; Bourgeois, Stephane; Drozda, Katarzyna; Burmester, James K; Tsunoda, Tatsuhiko; Nakamura, Yusuke; Kubo, Michiaki; Tector, Matthew; Limdi, Nita A; Cavallari, Larisa H; Perera, Minoli; Johnson, Julie A; Klein, Teri E; Altman, Russ B (BioMed Central, 2013-05)
      Background: Many genome-wide association studies focus on associating single loci with target phenotypes. However, in the setting of rare variation, accumulating sufficient samples to assess these associations can ...