Now showing items 1-4 of 4
Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition
(Oxford University Press, 2013-08)
Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery. Because cells have many different RS, usually one for each ...
Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan***not yet published***
(Oxford University Press, 2013-10)
A transcriptional attenuation mechanism regulates expression of the bacterial tnaCAB operon. This mechanism requires ribosomal arrest induced by the regulatory nascent TnaC peptide in response to free L-tryptophan (L-Trp). ...
The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics
(National Academy of Sciences, 2010)
Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei, binds at the peptidyl transferase center of the ubacterial large ribosomal subunit. Biochemical and ...
Nascent Peptide in the Ribosome Exit Tunnel Affects Functional Properties of the A-site of the Peptidyl Transferase Center
(Elsevier (Cell Press), 2011-02-04)
The ability to monitor the nascent peptide structure and to respond functionally to specific nascent peptide sequences is a fundamental property of the ribosome. An extreme manifestation of such response is nascent ...