Now showing items 1-5 of 5
Minimal Prolongation of Prothrombin Time with Extended Exposure to Argatroban.
In the setting of acute heparin-induced thrombocytopenia (HIT), argatroban is one of the initial anticoagulants of choice, which is eventually bridged to warfarin over a period of 5 or more days. Argatroban prolongs ...
Association of the GGCX (CAA)16/17 repeat polymorphism with higher warfarin dose requirements in African Americans
(Lippincott, Williams & Wilkins, 2012-02)
Objective Little is known about genetic contributors to higher than usual warfarin dose requirements, particularly for African Americans. This study tested the hypothesis that the γ-glutamyl carboxylase (GGCX) genotype ...
Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism
(Nature Publishing Group, 2012-04)
The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a ...
Association of Apolipoprotein E Genotype with Duration of Time to Achieve a Stable Warfarin Dose in African-American Patients
(IOS Press, 2011-08)
Study Objective. To test the hypothesis that genotypes for proteins affecting vitamin K availability influence the duration of time required to achieve a stable warfarin dose in African-American patients. Design. ...
The Role of Pharmacogenomics in the Management of Traditional and Novel Oral Anticoagulants
(IOS Press, 2011-12)
Warfarin is the most commonly prescribed oral anticoagulant. However, it remains a difficult drug to manage mostly because of its narrow therapeutic index and wide inter-patient variability in anticoagulant effects. Over ...