Now showing items 1-10 of 24
Let-7 micro RNAs and opioid tolerance
(Frontiers Research Foundation, 2012-06-21)
This chapter will focus on the role of microRNAs (miRs) in regulating the actions of opioid drugs through the opioid receptors. Opioids, such as morphine, are analgesics that are used for treating many forms of acute and ...
Economic Analysis of Alvimopan for Prevention and Management of Postoperative Ileus
(IOS Press, 2012-02)
Objective: To determine whether alvimopan for prevention of post-operative ileus (POI) among patients undergoing small- or large-bowel resection via laparotomy is associated with lower total costs compared to standard ...
Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein
(Public Library of Science, 2012-02)
Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. In this study the herb-drug interactions between S. flavescens ...
Analysis and Purification of Bioactive Natural Products: The AnaPurNa Study
(Journal of Natural Products, 2012-06)
Based on a meta-analysis of data mined from almost 2000 publications on bioactive natural products (NPs) from >80 000 pages of 13 different journals published in 1998−1999, 2004−2005, and 2009−2010, the aim of this ...
VIP-targeted Cytotoxic Nanomedicine for Breast Cancer
(Springer Verlag, 2012-12)
Cancer chemotherapy is hampered by serious toxicity to healthy tissues. Conceivably, encapsulation of cytotoxic drugs in actively-targeted, biocompatible nanocarriers could overcome this problem. Accordingly, we used ...
Training Future Health Providers to Care for the Underserved: A Pilot Interprofessional Experience
(Medknow Publications, 2012-09)
Introduction: Interprofessional teamwork is essential for effective delivery of health care to all patients, particularly the vulnerable and underserved. This brief communication describes a pilot interprofessional learning ...
Impact of 5-HT3 receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study
(BioMed Central, 2012-07)
Background: 1st generation 5-hydroxytryptamine receptor antagonists (5-HT3 RAs), and palonosetron, a 2nd generation 5-HT3 RA, are indicated for the prevention of chemotherapy (CT)-induced nausea and vomiting (CINV) associated ...
Cost is not a barrier to implementing clopidogrel pharmacogenetics
(IOS Press, 2012-04)
Thermoregulation of Capsule Production by Streptococcus pyogenes
(Public Library of Science, 2012-05)
The capsule of Streptococcus pyogenes serves as an adhesin as well as an anti-phagocytic factor by binding to CD44 on keratinocytes of the pharyngeal mucosa and the skin, the main entry sites of the pathogen. We discovered ...
Tailoring Drug Therapy Based on Genotype
(SAGE Publications, 2012-08)
Polymorphisms in genes encoding drug metabolizing enzymes, drug transporters, and drug targets can influence drug effects and contribute to inter-individual differences in drug response. Genotype for drug metabolizing ...