The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia
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Date
2015Author
Bonaccorso, S.
Sodhi, MS
Li, S.
Bobo, WV
Chen, Y.
Tumuklu, M.
Publisher
Wiley Periodicals Inc.Metadata
Show full item recordAbstract
Objectives: We tested the hypothesis that a common functional variant
in brain-derived neurotrophic factor (BDNF), Val66Met, which has
been shown to be associated with increased body mass index (BMI) in
schizophrenia (SCZ) and schizoaffective disorder (SAD), is also
associated with antipsychotic-induced weight gain in bipolar disorder
(BPD). Association of Val66Met with other metabolic measures,
including high- and low-density cholesterol, triglycerides, total
cholesterol, fasting blood glucose, and hemoglobin A1c, was also tested.
Methods: This was a 12-month, prospective, randomized trial of two
atypical antipsychotic drugs (APDs) with moderate (risperidone) or high
(olanzapine) risk to cause weight gain. Subjects were diagnosed as
having BPD (n = 90) and SCZ or SAD (n = 76).
Results: BMI was significantly greater in all diagnoses for Met66 allele
carriers at six months (p = 0.01). Met66 carriers with BPD showed a
greater increase in the triglycerides/high-density (HDL) cholesterol ratio
(p = 0.01), a key marker for metabolic syndrome related to insulin
resistance, and log-triglycerides (p = 0.04), after three or six months of
treatment. Met66 carriers had the greatest increase in log-triglycerides
(p = 0.03) and triglycerides/HDL cholesterol ratio after three months of
treatment with risperidone (p = 0.003), and the highest BMI at six
months (p = 0.01).
Conclusions: The positive association of BNDF Val66Met with high
BMI values replicates previous findings in patients with SCZ and
indicates the BDNF Val66Met genotype as a potential risk factor for
obesity and insulin resistance measures in patients with BPD receiving
antipsychotics as well.
Subject
antipsychotic drugsbrain-derived neurotrophic factor (BDNF) Val66Met
bipolar disorder
body mass index
glucose
lipids
schizophrenia