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dc.contributor.advisorBraunschweig, Carolen_US
dc.contributor.authorGomez-Perez, Sandra L.en_US
dc.date.accessioned2016-02-17T17:32:14Z
dc.date.available2018-02-18T10:30:10Z
dc.date.created2015-12en_US
dc.date.issued2016-02-17
dc.date.submitted2015-12en_US
dc.identifier.urihttp://hdl.handle.net/10027/20236
dc.description.abstractIntroduction: Excess visceral adipose tissue (VAT) associates with inflammation, insulin resistance(IR) and colorectal cancer (CRC) risk. Compared to Non-Hispanic Whites (NHW), healthy African Americans (AA) have less VAT but increased risk for IR and CRC. The association between VAT, CRC and race/ethnicity is unclear. Methods: A case-control study (N=256; 128 cases, 128 controls) of AA and NHW patients with and without incident CRC characterized the relationship between abdominal adipose tissues (AAT), CRC and race/ethnicity. Cross-sectional computed tomography(CT) images were quantified for abdominal circumference (WC), VAT and other AAT. A cross-sectional analysis of serum samples from cases were used to assess the association between AAT, race/ethnicity and CRC. Also, a cross-sectional analysis was also used to explore the existence of hepatic steatosis by measuring hepatic fat content(HFC) in both groups. Results: Median and interquartile for age, body mass index (BMI), and WC were 62(10)years, 27(7)kg/m2 and 104(17)cm, respectively; sample was 79%(176/256) AA, 63%(158/256). Also, 28%(35/128) of cases and 31%(39/128) were obese (BMI≥30). No significant differences were found for VAT between cases and controls (p=0.9316) however, superficial subcutaneous adipose tissue (SSAT) was significantly higher in cases (p=0.0005). AA cases and controls had significantly lower VAT compared to NHW counterparts. Conditional logistic regression revealed that SSAT reduced the odds of CRC for AA only (OR: 0.24, 95%CI 0.07-0.85). Adiponectin and insulin-growth factor binding protein-3 were significantly lower in AA males compared to NHW males. The non-contrast technique of CT images showed lower prevalence of HFC for overall sample. Conclusions: No VAT-related CRC phenotype was found between cases and controls. Differences in VAT between AA and NHW cases versus controls resembles the body composition phenotype of healthy populations. The role of SSAT as protective against CRC requires further investigation especially in light of its accessibility for biopsy studies and the availability of new inexpensive and risk - free techniques for measuring SSAT using an ultrasound. The role of VAT and other AAT in the CRC pathway remains to be determined.en_US
dc.language.isoenen_US
dc.rightsen_US
dc.rightsCopyright 2015 Sandra L. Gomez-Perezen_US
dc.subjectcolorectal canceren_US
dc.subjectbody compositionen_US
dc.subjectcomputed tomographyen_US
dc.subjectrace/ethnicityen_US
dc.titleBody Composition and Biomarkers of Colorectal Cancer Risk in African Americans and Non-Hispanic Whitesen_US
thesis.degree.departmentKinesiology and Nutritionen_US
thesis.degree.disciplineKinesiology and Nutritionen_US
thesis.degree.grantorUniversity of Illinois at Chicagoen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhD, Doctor of Philosophyen_US
dc.type.genrethesisen_US
dc.contributor.committeeMemberFantuzzi, Giamilaen_US
dc.contributor.committeeMemberFreels, Sallyen_US
dc.contributor.committeeMemberChaudhry, Viveken_US
dc.contributor.committeeMemberMar, Winnieen_US
dc.type.materialtexten_US


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