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dc.contributor.authorWolf, Andrew B.
dc.contributor.authorValla, Jon
dc.contributor.authorBu, Guojun
dc.contributor.authorKim, Jungsu
dc.contributor.authorLaDu, Mary Jo
dc.contributor.authorReiman, Eric M.
dc.contributor.authorCaselli, Richard J.
dc.date.accessioned2016-04-12T17:40:12Z
dc.date.available2016-04-12T17:40:12Z
dc.date.issued2013
dc.identifier.bibliographicCitationWolf, A. B., Valla, J., Bu, G. J., Kim, J., LaDu, M. J., Reiman, E. M. and Caselli, R. J. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. alzheimers research & therapy. 2013. 5(5). DOI: 10.1186/alzrt204.en_US
dc.identifier.issn1758-9193
dc.identifier.urihttp://hdl.handle.net/10027/20430
dc.description.abstractAPOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer’s disease. Current understanding of Alzheimer’s disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas.en_US
dc.description.sponsorshipThis work was supported by the Arizona Alzheimer’s Consortium, the State of Arizona, the Arizona Alzheimer’s Disease Core Center (P30 AG19610), and the University of Colorado Medical Scientist Training Program (NIGMS 5T32GM008497-20).en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.titleApolipoprotein E as a β-amyloid-independent factor in Alzheimer's diseaseen_US
dc.typeArticleen_US


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