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dc.contributor.authorLi, WF
dc.contributor.authorWang, J
dc.contributor.authorZhang, JJ
dc.contributor.authorSong, X
dc.contributor.authorKu, CF
dc.contributor.authorZou, J
dc.contributor.authorLi, JX
dc.contributor.authorRong, LJ
dc.contributor.authorPan, LT
dc.contributor.authorZhang, HJ
dc.date.accessioned2016-05-09T14:52:51Z
dc.date.available2016-05-09T14:52:51Z
dc.date.issued2015-11-24
dc.identifier.bibliographicCitationLi, W. F., Wang, J., Zhang, J. J., Song, X., Ku, C. F., Zou, J., Li, J. X., Rong, L. J., Pan, L. T. and Zhang, H. J. Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi. Int J Mol Sci. 2015. 16(11): 27978-27987. DOI: 10.3390/ijms161126071.en_US
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10027/20540
dc.descriptionThis is a copy of an article published in the International Journal of Molecular Sciences © 2015 MDPI Publications.en_US
dc.description.abstractHenrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).en_US
dc.description.sponsorshipThe work described in this paper was collaborative efforts within multi-disciplinary cooperative programs supported by grants from by the Natural Science Foundation Committee of China (81160496), the Science and Technology Fund of Guizhou Province (No. [2009]2145), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKBU 262912 and HKBU12103014), HKBU Interdisciplinary Research Matching Scheme (RC-IRMS/12-13/03), and Faculty Research Grants, Hong Kong Baptist University (FRG2/14-15/047 and FRG1/13-14/029).en_US
dc.publisherMDPIen_US
dc.subjectPteris henryien_US
dc.subjectent-kaurane diterpeneen_US
dc.subjecthenrin Aen_US
dc.subjectbioactivity evaluationen_US
dc.subjectanti-HIV activityen_US
dc.titleHenrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.en_US
dc.typeArticleen_US


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