Show simple item record

dc.contributor.authorPandey, GN
dc.contributor.authorRen, X
dc.contributor.authorRizavi, HS
dc.contributor.authorZhang, H
dc.date.accessioned2016-05-12T20:54:08Z
dc.date.available2016-05-12T20:54:08Z
dc.date.issued2015-09
dc.identifier.bibliographicCitationPandey, G. N., Ren, X. G., Rizavi, H. S. and Zhang, H. Abnormal gene expression of proinflammatory cytokines and their receptors in the lymphocytes of patients with bipolar disorder. Bipolar Disorders. 2015. 17(6): 636-644. DOI: 10.1111/bdi.12320.en_US
dc.identifier.issn1398-5647
dc.identifier.urihttp://hdl.handle.net/10027/20626
dc.descriptionThis is the pre-peer reviewed version of the following article: Pandey, G. N., Ren, X. G., Rizavi, H. S. and Zhang, H. Abnormal gene expression of proinflammatory cytokines and their receptors in the lymphocytes of patients with bipolar disorder. Bipolar Disorders. 2015. 17(6): 636-644. 10.1111/bdi.12320.en_US
dc.description.abstractObjectives: Abnormalities of protein levels of proinflammatory cytokines and their soluble receptors have been reported in plasma of bipolar (BP) patients. In this study we tested the hypothesis that the mRNA expression of membrane-bound receptors for proinflammatory cytokines will be altered in the lymphocytes of BP patients. Methods: We determined protein and mRNA expression of proinflammatory cytokines, and mRNA expression of their receptors in the lymphocytes from 29 drug-free, hospitalized BP patients and 30 drug-free normal control subjects. The subjects were diagnosed according to DSM-IV criteria. Plasma protein levels of cytokines were determined by ELISA; mRNA levels in lymphocytes were determined by the qPCR method. Results: We found that mean mRNA levels of proinflammatory cytokines IL-1β, IL-6, TNF-α, their receptors, TNFR1, IL-1R1, and the antagonist IL-1RA were significantly higher in the lymphocytes of BP patients compared with normal controls. Conclusions: This study suggests that the observed abnormalities of membrane-bound cytokine receptors may alter the functional response of cytokines in BP illness and that the mRNA levels of these receptors could be a potential biomarker.en_US
dc.description.sponsorshipThis research was supported by a grant RO1-MH-56528 (Dr. Pandey) from the National Institute of Mental Health, Rockville, MD.en_US
dc.publisherWileyen_US
dc.subjectbiomarkersen_US
dc.subjectproinflammatoryen_US
dc.subjectcytokinesen_US
dc.subjectcytokine receptorsen_US
dc.subjectbipolar illnessen_US
dc.subjectlymphocytesen_US
dc.subjectIL-1 receptorsen_US
dc.subjectIL-6 receptorsen_US
dc.subjectTNF-α receptorsen_US
dc.subjectgene expressionen_US
dc.subjectmRNAen_US
dc.titleAbnormal gene expression of proinflammatory cytokines and their receptors in the lymphocytes of patients with bipolar disorder.en_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record