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dc.contributor.authorDaghfous G
dc.contributor.authorGreen WW
dc.contributor.authorAlford, Simon
dc.contributor.authorZielinski BS
dc.contributor.authorDubuc R
dc.date.accessioned2016-08-02T16:08:21Z
dc.date.available2016-08-02T16:08:21Z
dc.date.issued2016-03-22
dc.identifier.bibliographicCitationDaghfous, G., Green, W. W., Alford, S. T., Zielinski, B. S. and Dubuc, R. Sensory activation of command cells for locomotion and modulatory mechanisms: Lessons from lampreys. Frontiers in Neural Circuits. 2016. 10(MAR). DOI: 10.3389/fncir.2016.00018.en_US
dc.identifier.otherESSN: 1662-5110
dc.identifier.urihttp://hdl.handle.net/10027/21010
dc.descriptionThis is a copy of an article published in Frontiers in Neural Circuits. © 2016 Frontiers Media Publications. © 2016 Daghfous, Green, Alford, Zielinski and Dubuc.en_US
dc.description.abstractSensorimotor transformation is one of the most fundamental and ubiquitous functions of the central nervous system (CNS). Although the general organization of the locomotor neural circuitry is relatively well understood, less is known about its activation by sensory inputs and its modulation. Utilizing the lamprey model, a detailed understanding of sensorimotor integration in vertebrates is emerging. In this article, we explore how the vertebrate CNS integrates sensory signals to generate motor behavior by examining the pathways and neural mechanisms involved in the transformation of cutaneous and olfactory inputs into motor output in the lamprey. We then review how 5-hydroxytryptamine (5-HT) acts on these systems by modulating both sensory inputs and motor output. A comprehensive review of this fundamental topic should provide a useful framework in the fields of motor control, sensorimotor integration and neuromodulation.en_US
dc.description.sponsorshipWe acknowledge the support of the Great Lakes Fishery Commission over the years, as group grants to BZ and RD (GLFC, 54011, 54021, 54035). Group Grants provide the necessary conditions to promote in-depth reviews of this kind. This work was also supported by a grant to RD from the Natural Sciences and Engineering Research Council of Canada (NSERC, 217435), a grant from the Canadian Institutes of Health Research (CIHR, 15129) and a group grant from the Fonds de Recherche du Québec - Santé (FRQS, 5249).en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Mediaen_US
dc.subject5-HTen_US
dc.subjectlampreyen_US
dc.subjectlocomotionen_US
dc.subjectmodulationen_US
dc.subjectreticulospinal neuronsen_US
dc.subjectsensorimotoren_US
dc.titleSensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.en_US
dc.typeArticleen_US


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