Now showing items 1-20 of 1093

    • Informatics and hypothesis-driven research 

      Smalheiser, Neil R. (2002)
    • Informatics tools for scientific discovery and collaboration. 

      Smalheiser, Neil R.; Swanson, Don R; Torvik, VI; Palmer, C; Cragin, M; Hogan, T; West, R; Bischoff-Grethe, A; Yu, C (2003)
    • An introduction to Medline searching. 

      Swanson, Don R (2003)
    • Towards effective and rewarding data sharing [Editorial] 

      Gardner, Daniel; Toga, Arthur W.; Ascoli, Giorgio A.; Beatty, Jackson; Brinkley, James F.; Dale, Anders M.; Fox, Peter T.; Gardner, Esther P.; George, John S.; Goddard, Nigel; Harris, Kristen M.; Herskovits, Edward H.; Hines, Michael; Jacobs, Gwen A.; Jacobs, Russell E.; Jones, Edward G.; Kennedy, David N.; Kimberg, Daniel Y.; Mazziotta, John C.; Miller, Perry; Mori, Susumu; Mountain, David C.; Reiss, Allan L.; Rosen, Glenn D.; Rottenberg, David A.; Shepherd, Gordon M.; Smalheiser, Neil R.; Smith, Kenneth P.; Strachan, Tom; Van Essen, David C.; Williams, Robert W.; Wong, Stephen T. (Humana Press, 2003)
    • Knowledge Discovery in Medline and Other Databases. 

      Smalheiser, Neil R. (Washington, DC: Society for Neuroscience, 2003)
      All neuroscientists are in the business of discovering knowledge about how the brain works. However, only a portion of time is spent in making new discoveries in the laboratory or clinic. An increasingly large task is ...
    • G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus 

      Kino, Tomoshige; Tiulpakov, Anatoly; Ichijo, Takamasa; Chheng, Ly; Kozasa, Tohru; Chrousos, George P. (Rockefeller University Press, 2005-06)
      Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated ...
    • Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the G(s) G protein 

      Freudzon, Leon; Norris, Rachael P.; Hand, Arthur R.; Tanaka, Shigeru; Saeki, Yoshinaga; Jones, Teresa L.Z.; Rasenick, Mark M.; Berlot, Catherine H.; Mehlmann, Lisa M.; Jaffe, Laurinda A. (Rockefeller University Press, 2005-10)
      The arrest of meiotic prophase in mouse oocytes within antral follicles requires the G protein G(s) and an orphan member of the G protein-coupled receptor family, GPR3. To determine whether GPR3 activates G(s), the ...
    • The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts 

      Todorovic, Viktor; Chen, Chih-Chiun; Hay, Nissim; Lau, Lester F. (Rockefeller University Press, 2005-11-07)
      Integrin-mediated cell adhesion to extracellular matrix proteins is known to promote cell survival, whereas detachment from the matrix can cause rapid apoptotic death in some cell types. Contrary to this paradigm, we show ...
    • AID-dependent histone acetylation is detected in immunoglobulin S regions 

      Wang, Lili; Whang, Naree; Wuerffel, Robert; Kenter, Amy L. (Rockefeller University Press, 2006-01-17)
      Class switch recombination (CSR) is regulated by the expression of activation-induced deaminase ( AID) and germline transcripts (GLTs). AID-dependent double-strand breaks (DSBs) are introduced into switch ( S) regions and ...
    • CIB1 is an endogenous inhibitor of agonist-induced integrin aIIbb3 [alpha II b beta 3]activation 

      Yuan, Weiping; Leisner, Tina M; McFadden, Andrew W; Wang, Zhengyan; Larson, Mark K; Clark, Shantres; Boudignon-Proudhon, Christel; Lam, Stephen CT; Parise, Leslie V (Rockefeller University Press, 2006-01-17)
      In response to agonist stimulation, the alpha IIb beta 3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis ...
    • Nuclear actin: to polymerize or not to polymerize 

      Hofmann, Wilma A.; de Lanerolle, Primal (Rockefeller University Press, 2006-02-13)
      The form and function of actin in the nucleus have been enigmatic for over 30 years. Recently actin has been assigned numerous functional roles in the nucleus, but its form remains a mystery. The intricate relationship ...
    • Aiding Biomedical Researchers with Tools to Assist Discovery 

      Smalheiser, Neil R. (2006-05-18)
      The Arrowsmith Project two node search is used for many daily information needs as an extension of PubMed searches. The two node search can now be conducted and analyzed in a matter of minutes, not hours or days, and it ...
    • Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators 

      Smalheiser, Neil R.; Torvik, Vetle I.; Bischoff-Grethe, Amanda; Burhans, Lauren B.; Gabriel, Michael; Homayouni, Ramin; Kashef, Alireza; Martone, Maryann E; Perkins, Guy A; Price, Diana L; Talk, Andrew C; West, Ruth (Journal of Biomedical Discovery and Collaboration 2006, 1:8, 2006-07-03)
      Arrowsmith is a unique computer-assisted strategy designed to assist investigators in detecting biologically-relevant connections between two disparate sets of articles in Medline. This paper describes how an inter-institutional ...
    • Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity 

      Horiguchi, Kaori; Hanada, Toshihiko; Fukui, Yasuhisa; Chishti, Athar H. (Rockefeller University Press, 2006-07-24)
      Phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), a product of phosphatidylinositol 3-kinase, is an important second messenger implicated in signal transduction and membrane transport. In hippocampal neurons, the accumulation ...
    • Author Name Disambiguation in Medline 

      Torvik, Vetle I.; Smalheiser, Neil R. (2006-08-31)
    • ADAM: Another Database of Abbreviations in MEDLINE 

      Zhou, Wei; Torvik, Vetle I.; Smalheiser, Neil R. (Bioinformatics Advance Access, 2006-09-18)
      Motivation: Abbreviations are an important type of terminology in the biomedical domain. Although several groups have already created databases of biomedical abbreviations, these are either not public, or are not ...
    • ADAM: another database of abbreviations in MEDLINE 

      Zhou, Wei; Torvik, Vetle I.; Smalheiser, Neil R. (Bioinformatics, 2006-09-18)
      Motivation: Abbreviations are an important type of terminology in the biomedical domain. Although several groups have already created databases of biomedical abbreviations, these are either not public, or are not ...
    • A novel role for phagocytosis-like uptake in herpes simplex virus entry 

      Clement, Christian; Tiwari, Vaibhav; Scanlan, Perry M; Valyi-Nagy, Tibor; Yue, Beatrice Y; Shukla, Deepak (Rockefeller University Press, 2006-09-26)
      It is becoming increasingly clear that herpesviruses can exploit the endocytic pathway to infect cells, yet several important features of this process remain poorly defined. Using herpes simplex virus-1 (HSV-1) as a model, ...