Now showing items 1-3 of 3

    • APOE4-specific Changes in A beta Accumulation in a New Transgenic Mouse Model of Alzheimer Disease 

      Youmans, Katherine L.; Tai, Leon M.; Nwabuisi-Heath, Evelyn; Jungbauer, Lisa; Kanekiyo, Takahisa; Gan, Ming; Kim, Jungsu; Eimer, William A.; Estus, Steve; Rebeck, G. William; Weeber, Edwin J; Bu, Guojun; Yu, Chunjiang; LaDu, Mary Jo (American Society for Biochemistry and Molecular Biology, 2012-12)
      APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-beta peptide (A beta) suggest interactions among apoE isoforms and different forms of A beta accumulation. However, it remains ...
    • Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms 

      Li, Jie; Kanekiyo, Takahisa; Shinohara, Mitsuru; Zhang, Yunwu; LaDu, Mary Jo; Xu, Huaxi; Bu, Guojun (American Society for Biochemistry and Molecular Biology, 2012-12)
      Aggregation of amyloid-beta (A beta) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major A beta clearance pathway in the brain is cellular uptake and degradation. However, how A ...
    • Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody 

      Youmans, Katherine L.; Tai, Leon M.; Kanekiyo, Takahisa; Stine Jr, W Blaine; Michon, Sara-Claude; Nwabuisi-Heath, Evelyn; Manelli, Arlene M.; Fu, Yifan; Riordan, Sean; Eimer, William A; Binder, Lester; Bu, Guojun; Yu, Chunjiang; Hartley, Dean M.; LaDu, Mary Jo (BioMed Central, 2012)
      Background: The form(s) of amyloid-b peptide (Ab) associated with the pathology characteristic of Alzheimer’s disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Ab accumulation is an issue ...