Now showing items 1-2 of 2

    • APOE4-specific Changes in A beta Accumulation in a New Transgenic Mouse Model of Alzheimer Disease 

      Youmans, Katherine L.; Tai, Leon M.; Nwabuisi-Heath, Evelyn; Jungbauer, Lisa; Kanekiyo, Takahisa; Gan, Ming; Kim, Jungsu; Eimer, William A.; Estus, Steve; Rebeck, G. William; Weeber, Edwin J; Bu, Guojun; Yu, Chunjiang; LaDu, Mary Jo (American Society for Biochemistry and Molecular Biology, 2012-12)
      APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-beta peptide (A beta) suggest interactions among apoE isoforms and different forms of A beta accumulation. However, it remains ...
    • Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease 

      Wolf, Andrew B.; Valla, Jon; Bu, Guojun; Kim, Jungsu; LaDu, Mary Jo; Reiman, Eric M.; Caselli, Richard J. (BioMed Central, 2013)
      APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer’s disease. Current understanding of Alzheimer’s disease pathophysiology posits an important role ...