Browsing Publications - Medicinal Chemistry and Pharmacognosy by Subject "Antidepressant-like effects"

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Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists

Zhang, Han-Kun; Eaton, J. Brek; Fedolak, Allison; Gunosewoyo, Hendra; Onajole, Oluseye K.; Brunner, Dani; Lukas, Ronald J.; Yu, Li-Fang; Kozikowski, Alan P. (Elsevier Masson SAS, 2016-11-29)

We previously reported the cyclopropylpyridine and isoxazolylpyridine ether scaffolds to be versatile building blocks for creating potent α4β2 nicotinic acetylcholine receptor (nAChR) partial agonists with excellent ...