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Advances in protein turnover analysis at the global level and biological insights
The concept of a dynamic state of body constituents, a precursor of the modern term of proteome dynamics, was conceived over a century ago. But, not until recently can we examine the dynamics of individual ‘constituents’ ...
Assigning significance in label-free quantitative proteomics to include single-peptide-hit proteins with low replicates
(Hindawi Publishing Corporation, 2010-01-01)
Selecting differentially regulated proteins with an assignment of statistical significance remains difficult for proteins with a single-peptide hit or a small fold-change when sample replicates are limited. This study ...