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dc.contributor.authorMehta, Supriya D.
dc.contributor.authorKrieger, John N.
dc.contributor.authorAgot, Kawango
dc.contributor.authorMoses, Stephen
dc.contributor.authorNdinya-Achola, Jeckoniah O.
dc.contributor.authorParker, Corette
dc.contributor.authorBailey, Robert C.
dc.date.accessioned2011-03-01T03:28:35Z
dc.date.available2011-03-01T03:28:35Z
dc.date.issued2010-07
dc.identifier.bibliographicCitationMehta, S. D., Krieger, J. N., Agot, K., Moses, S., Ndinya-Achola, J. O., Parker, C., & Bailey, R. C. 2010. Circumcision and reduced risk of self-reported penile coital injuries: results from a randomized controlled trial in kisumu, kenya. Journal of Urology., 184(1): 203-209. DOI: 10.1016/j.juro.2010.03.015en
dc.identifier.issn1527-3792
dc.identifier.otherDOI: 10.1016/j.juro.2010.03.015
dc.identifier.urihttp://hdl.handle.net/10027/7355
dc.descriptionPost print version of article may differ from published version. The definitive version is available through Elsevier at DOI: 10.1016/j.juro.2010.03.015en
dc.description.abstractPurpose: Injuries to the penis during intercourse represent one hypothesized mechanism by which uncircumcised men are at increased risk for HIV. There are no published, systematically collected data regarding mild penile coital trauma. We identified risks for self-reported penile coital injuries in men aged 18-24 in our randomized trial of circumcision to prevent HIV in Kisumu, Kenya. Materials and Methods: Each participant underwent standardized interview, medical history, and physical examination, at baseline and 6, 12, 18, and 24 months after enrollment. Self-reported penile coital injuries were assessed at each visit: penis feels sore during sex; penis gets scratches, cuts or abrasions during sex; skin of the penis bleeds after sex. Generalized estimating equation analysis estimated odds ratios (OR) for penile coital injuries. Results: February 2002-September 2005, 2,784 participants were randomized. At baseline, 1,775 (64.4%) men reported any coital injury: 1,313 (47.6%) soreness; 1,328 (48.2%) scratches, abrasions, or cuts; 461 (16.7%) bleeding. In multivariable analysis, coital injury risk was lower for circumcised than uncircumcised men: soreness [OR=0.71, 95% CI 0.64-0.80], scratches/abrasions/cuts [OR=0.52, 95% CI 0.46-0.59], bleeding [OR=0.62, 95% CI 0.51-0.75], any coital injury [OR=0.61, 95% CI 0.54-0.68]. Other significant risks (p<0.05) included: increasing age, multiple recent sex partners, HSV-2 seropositivity, and genital ulcers. Condom use, cleaning the penis soon after intercourse, and being married/cohabiting were protective (p<0.05, each). Conclusions: Self-reported penile coital injuries were common in these healthy young men. Circumcised men were at lower risk for coital injuries. Verifying penile coital injuries, mechanism of acquisition, and association with HIV risk is needed.en
dc.description.sponsorshipThis research was supported by grant number AI50440 from the Division of AIDS, National Institute of Allergies and Infectious Disease of the United States National Institutes of Health, and by grant number HCT 44180 from the Canadian Institutes of Health Research (CIHR).en
dc.language.isoen_USen
dc.publisherElsevieren
dc.subjectpenile coital injuriesen
dc.subjectintercourseen
dc.subjectHIVen
dc.subjectcircumcisionen
dc.titleCircumcision and reduced risk of self-reported penile coital injuries: results from a randomized controlled trial in Kisumu, Kenyaen
dc.typeArticleen


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