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Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36
(American Society for Biochemistry and Molecular Biology, 2013-01)
Cardiac triacylglycerol (TAG) stores buffer the intracellular availability of long chain fatty acid (LCFA) that act as nuclear receptor ligands, substrate for lipotoxic derivatives, and high energy-yield fuel. The kinetic ...
Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPAR{alpha}
(American Heart Association, 2010-07-23)
Rationale: Long chain fatty acids (LCFAs) are the preferred substrate for energy provision in hearts. However, the contribution of endogenous triacylglyceride (TAG) turnover to LCFA oxidation and the overall dependence of ...
In vivo, cardiac-specific knockdown of target protein, Malic Enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA
(Bentham Science Publishers, 2012-12)
This study examines the feasibility of using the adenoviral delivery of DNA for a non-native microRNA to suppress
expression of a target protein (cytosolic NADP+-dependent malic-enzyme 1, ME1) in whole heart in vivo, via ...