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CRACing the cluster: functionally active Orai1 channels in the absence of clustering with STIM1

Smith, Kimberly A.; Yuan, Jason X.-J. (American Heart Association, 2012-06)

Antioxidant Therapy for Atrial Fibrillation: Lost in Translation?

Sovari, Ali A.; Dudley, Samuel C. Jr. (BMJ Publishing Group, 2012-11)

Despite considerable evidence suggesting a central role for oxidative stress in pathogenesis of atrial fibrillation (AF), use of conventional reactive oxygen species (ROS) scavengers have not shown impressive results. ROS ...

Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE2 Production in Bone Marrow Derived Macrophages

Xiao, Lei; Ornatowska, Magdalena; Zhao, Guiqing; Cao, Hongmei; Yu, Rui; Deng, Jing; Li, Yongchao; Zhao, Qiong; Sadikot, Ruxana T.; Christman, John W. (Public Library of Science, 2012-11)

Cyclooxygenase (COX)-2 expression and release of prostaglandins (PGs) by macrophages are consistent features of lipopolysaccharide (LPS)-induced macrophage inflammation. The two major PGs, PGE(2) and PGD(2), are synthesized ...

Reactive oxygen species-targeted therapeutic interventions for atrial fibrillation

Sovari, Ali A.; DudleyJr., Samuel C. (Frontiers Research Foundation, 2012)

Atrial fibrillation (AF) is the most common arrhythmia that requires medical attention, and its incidence is increasing. Current ion channel blockade therapies and catheter ablation have significant limitations in treatment ...

Enhanced Ca2+-sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension

Yamamura, Aya; Guo, Qiang; Yamamura, Hisao; Zimnicka, Adriana M.; Pohl, Nicole M.; Smith, Kimberly A.; Fernandez, Ruby A.; Zeifman, Amy; Makino, Ayako; Dong, Hui; Yuan, Jason X.-J. (American Heart Association, 2012-08)

Rationale: A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) in pulmonary arterial smooth muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular remodeling. Increased resting [Ca2+]cyt ...

In vivo, cardiac-specific knockdown of target protein, Malic Enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA

O’Donnell, J. Michael; Kalichira, Asha; Bi, Jian; Lewandowski, E. Douglas (Bentham Science Publishers, 2012-12)

This study examines the feasibility of using the adenoviral delivery of DNA for a non-native microRNA to suppress expression of a target protein (cytosolic NADP+-dependent malic-enzyme 1, ME1) in whole heart in vivo, via ...