Now showing items 17-27 of 27

    • Patient Safety Event Reporting Expectation: Does it Influence Residents’ Attitudes and Reporting Behaviors? 

      Boike, Justin R.; Bortman, Jared S.; Radosta, Jonathan M.; Turner, Crescent L.; Anderson-Shaw, Lisa; Centomani, Nikki M.; Chamberlin, William H.; Mayer, David; McDonald, Timothy; Goldstein, Jay L. (Lippincott, Williams & Wilkins, 2013-06)
      The use of live bacteria in cancer therapies offers exciting possibilities. Nowadays, an increasing number of genetically engineered bacteria are emerging in the field, with applications both in therapy and diagnosis. In ...
    • Perineural dexamethasone added to local anesthesia for brachial plexus block improves pain but delays block onset and motor blockade recovery 

      Knezevic, N.N.; Anantamongkol, U.; Candido, K.D. (American Society of Interventional Pain Physicians, 2015-01)
      BACKGROUND: Multiple studies have shown that perineural dexamethasone improves postoperative analgesia. However, some studies have shown minimal benefit, and have raised concerns regarding adverse physio-chemical effects ...
    • Reduced expression of angiotensin I-converting enzyme in Caveolin-1 knockout mouse lungs 

      Maniatis, Nikolaos A.; Balyasnikova, Irina V.; Metzger, Roman; Castellon, Marciela; Visintine, David J.; Schwartz, David E.; Minshall, Richard D.; Danilov, Sergei M. (Elsevier, 2010-09)
      Reduced lung capillary expression of angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, and of caveolin-1, an important regulator of endothelial cell signalling, has been demonstrated ...
    • Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction. 

      Negi, SI; Jeong, EM; Shukrullah, I; Veleder, E; Jones, DP; Fan, TH; Varadarajan, S; Danilov, SM; Fukai, T; Dudley SC Jr, SC Jr (Hindawi Publishing Corporation, 2015-10-04)
      Animal models have suggested a role of renin-angiotensin system (RAS) activation and subsequent cardiac oxidation in heart failure with preserved ejection fraction (HFpEF). Nevertheless, RAS blockade has failed to show ...
    • Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress 

      Chen, W.; Epshtein, Y.; Ni, X.; Dull, R. O.; Cress, A. E.; Garcia, J. G. N.; Jacobson, J. R. (Nature Publishing Group, 2015-11-17)
      Simvastatin, an HMG-CoA reductase inhibitor, has lung vascular-protective effects that are associated with decreased agonist-induced integrin β4 (ITGB4) tyrosine phosphorylation. Accordingly, we hypothesized that endothelial ...
    • Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress. 

      Chen, W; Epshtein, Y; Ni, X; Dull, RO; Cress, AE; Garcia, JG; Jacobson, JR (Nature Publishing Group, 2015-11-17)
      Simvastatin, an HMG-CoA reductase inhibitor, has lung vascular-protective effects that are associated with decreased agonist-induced integrin β4 (ITGB4) tyrosine phosphorylation. Accordingly, we hypothesized that endothelial ...
    • S100B Raises the Alert in Subarachnoid Hemorrhage. 

      Chong ZZ (De Gruyter, 2016-10)
      Subarachnoid hemorrhage (SAH) is a devastating disease with high mortality and mobility, the novel therapeutic strategies of which are essentially required. The calcium binding protein S100B has emerged as a brain injury ...
    • Sevoflurane reduces clinical disease in a mouse model of multiple sclerosis 

      Polak, Paul E.; Dull, Randall O.; Kalinin, Sergey; Sharp, Anthony J.; Ripper, Richard; Weinberg, Guy; Schwartz, David E.; Rubinstein, Israel; Feinstein, Douglas L. (BioMed Central, 2012-12)
      Background: Inhalational anesthetics have been shown to influence T cell functions both in vitro and in vivo, in many cases inducing T cell death, suggesting that exposure to these drugs could modify the course of an ...
    • Src Phosphorylation of Endothelial Cell Surface ICAM-1 Mediates Neutrophil Adhesion and Contributes to the Mechanism of Lung Inflammation 

      Liu, Guoquan; Vogel, Stephen M.; Gao, Xiaopei; Javaid, Kamran; Hu, Guochang; Danilov, Sergei M.; Malik, Asrar B.; Minshall, Richard D. (American Heart Association, 2011-06)
      Objective: To determine whether TNFα-induced Src activation and ICAM-1 phosphorylation rapidly increases endothelial cell adhesivity and PMN sequestration independent of de novo ICAM-1 synthesis. Methods and Results: ...
    • Tissue Specificity of Human Angiotensin I-Converting Enzyme 

      Kryukova, O. V.; Tikhomirova, V. E.; Golukhova, E. Z.; Evdokimov, V. V.; Kalantarov, G. F.; Trakht, I. N.; Schwartz, D. E.; Dull, R. O.; Gusakov, A. V.; Uporov, I. V.; Kost, O. A.; Danilov, S. M. (Public Library of Science, 2015-11-01)
      Background: Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, as well as in reproductive functions, is expressed as a type-1 ...
    • Tissue Specificity of Human Angiotensin I-Converting Enzyme. 

      Kryukova, OV; Tikhomirova, VE; Golukhova, EZ; Evdokimov, VV; Kalantarov, GF; Trakht, IN; Schwartz, DE; Dull, RO; Gusakov, AV; Uporov, IV; Kost, OA; Danilov, SM (Public Library of Science, 2015-11-23)
      BACKGROUND: Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, as well as in reproductive functions, is expressed as a type-1 ...