Now showing items 1-3 of 3

    • IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis 

      Hvaring, Charlotte; Vujicic, Snezana; Aasly, Jan O.; Feinstein, Douglas L.; White, Linda R.; Boullerne, Anne I. (Elsevier, 2013-03)
      This study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. ...
    • The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes 

      Lisi, Lucia; Navarra, Pierluigi; Feinstein, Douglas L.; Russo, Cinzia D. (BioMed Central, 2010-01-05)
      Background: Reactive astrocytes are capable of producing a variety of pro-inflammatory mediators and potentially neurotoxic compounds, including nitric oxide (NO). High amounts of NO are synthesized following up-regulation ...
    • Sevoflurane reduces clinical disease in a mouse model of multiple sclerosis 

      Polak, Paul E.; Dull, Randall O.; Kalinin, Sergey; Sharp, Anthony J.; Ripper, Richard; Weinberg, Guy; Schwartz, David E.; Rubinstein, Israel; Feinstein, Douglas L. (BioMed Central, 2012-12)
      Background: Inhalational anesthetics have been shown to influence T cell functions both in vitro and in vivo, in many cases inducing T cell death, suggesting that exposure to these drugs could modify the course of an ...