Now showing items 1-4 of 4
The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia
(Wiley Periodicals Inc., 2015)
Objectives: We tested the hypothesis that a common functional variant in brain-derived neurotrophic factor (BDNF), Val66Met, which has been shown to be associated with increased body mass index (BMI) in schizophrenia ...
Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia
Background—Impairment of glutamate neurons which relay sensory and cognitive information from the medial dorsal thalamus to the dorsolateral prefrontal cortex and other cortical regions may contribute to the pathophysiology ...
Sex differences in GABAergic gene expressions occur in the anterior cingulate cortex in schizophrenia.
(Elsevier Inc., 2015)
GABAergic dysfunction has been strongly implicated in the pathophysiology of schizophrenia. In this study, we analyzed the expression levels of several GABAergic genes in the anterior cingulate cortex (ACC) of ...
Sex differences in glutamate receptor gene expression in major depression and suicide
(Nature Publishing Group, 2015)
Accumulating data indicate that the glutamate system is disrupted in major depressive disorder (MDD), and recent clinical research suggests that ketamine, an antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor ...