Now showing items 1-8 of 8
Tailoring Drug Therapy Based on Genotype
(SAGE Publications, 2012-08)
Polymorphisms in genes encoding drug metabolizing enzymes, drug transporters, and drug targets can influence drug effects and contribute to inter-individual differences in drug response. Genotype for drug metabolizing ...
Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism
(Nature Publishing Group, 2012-04)
The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a ...
Training Future Health Providers to Care for the Underserved: A Pilot Interprofessional Experience
(Medknow Publications, 2012-09)
Introduction: Interprofessional teamwork is essential for effective delivery of health care to all patients, particularly the vulnerable and underserved. This brief communication describes a pilot interprofessional learning ...
Interaction Between Lycium barbarum (Goji) and Warfarin: A Case Report
(IOS Press, 2012-03)
A markedly elevated INR time was observed in a 71 year-old Ecuadorean-American woman hospitalized following the consumption of Himalayan Goji Juice. The woman was managed with warfarin following knee surgery three months ...
Association of the GGCX (CAA)16/17 repeat polymorphism with higher warfarin dose requirements in African Americans
(Lippincott, Williams & Wilkins, 2012-02)
Objective Little is known about genetic contributors to higher than usual warfarin dose requirements, particularly for African Americans. This study tested the hypothesis that the γ-glutamyl carboxylase (GGCX) genotype ...
Going Past the Data for Temozolomide
(Springer Verlag, 2012-04)
The benefit of six cycles of adjuvant temozolomide was documented in a randomized phase III (EORTC‐NCIC CE.3) trial and this therapy, following combined temozolomide and radiation, is the standard of care for patients ...
Influence of Body Weight, Ethnicity, Oral Contraceptives and Pregnancy on the Pharmacokinetics of Azithromycin in Women of Child-Bearing Age
(American Society for Microbiology, 2012-02)
Women of child-bearing age commonly receive azithromycin for treatment of community acquired infections, including during pregnancy. This study determined azithromycin pharmacokinetics (PKs) in pregnant and nonpregnant ...
Cost is not a barrier to implementing clopidogrel pharmacogenetics
(IOS Press, 2012-04)