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dc.contributor.authorZhou, Tong
dc.contributor.authorWilke, Claus O.
dc.date.accessioned2011-05-27T16:13:32Z
dc.date.available2011-05-27T16:13:32Z
dc.date.issued2011-03-07
dc.identifier.bibliographicCitationZhou, T. & Wilke, C. O. 2011. Reduced stability of mRNA secondary structure near the translation-initiation site in dsDNA viruses. Bmc Evolutionary Biology, 11. DOI: 10.1186/1471-2148-11-59en
dc.identifier.issn1471-2148
dc.identifier.otherDOI: 10.1186/1471-2148-11-59
dc.identifier.urihttp://hdl.handle.net/10027/7731
dc.description© 2011 Zhou and Wilke; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1186/1471-2148-11-59en
dc.description.abstractBackground Recent studies have demonstrated a selection pressure for reduced mRNA secondary-structure stability near the start codon of coding sequences. This selection pressure can be observed in bacteria, archaea, and eukaryotes, and is likely caused by the requirement of efficient translation initiation in cellular organism. Results Here, we surveyed the complete genomes of 650 dsDNA virus strains for signals of reduced stability of mRNA secondary structure near the start codon. Our analysis included viruses infecting eukaryotic, prokaryotic, and archaeic hosts. We found that many viruses showed evidence for reduced mRNA secondary-structure stability near the start codon. The effect was most pronounced in viruses infecting prokaryotes, but was also observed in viruses infecting eukaryotes and archaea. The reduction in stability generally increased with increasing genomic GC content. For bacteriophage, the reduction was correlated with a corresponding reduction of stability in the phage hosts. Conclusions We conclude that reduced stability of the mRNA secondary structure near the start codon is a common feature for dsDNA viruses, likely driven by the same selective pressures that cause it in cellular organisms.en
dc.description.sponsorshipThis work was supported by NIH grant R01 GM088344.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.subjectvirusesen
dc.subjectstabilityen
dc.titleReduced stability of mRNA secondary structure near the translation-initiation site in dsDNA virusesen
dc.typeArticleen


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