Show simple item record

dc.contributor.authorDangaria, Smit J.
dc.contributor.authorIto, Yoshihiro
dc.contributor.authorYin, LeiLei
dc.contributor.authorValdre, Giovanni
dc.contributor.authorLuan, Xianghong
dc.contributor.authorDiekwisch, Thomas G.H.
dc.date.accessioned2011-05-27T16:37:45Z
dc.date.available2011-05-27T16:37:45Z
dc.date.issued2011-02
dc.identifier.bibliographicCitationDangaria, S. J., Ito, Y., Yin, L., Valdre, G., Luan, X., & Diekwisch, T. G. 2011. Apatite microtopographies instruct signaling tapestries for progenitor-driven new attachment of teeth. Tissue Eng Part A., 17(3-4): 279-290. DOI: 10.1089/ten.tea.2010.0264en
dc.identifier.issn1937-3341
dc.identifier.otherDOI: 10.1089/ten.tea.2010.0264
dc.identifier.urihttp://hdl.handle.net/10027/7738
dc.descriptionThis is a copy of an article published in Tissue Engineering Part A © 2011 Copyright Mary Ann Liebert, Inc.; Tissue Engineering Part A is available online at: http://www.liebertonline.com. (DOI: 10.1089/ten.tea.2010.0264)en
dc.description.abstractDimension and structure of extracellular matrix surfaces have powerful influences on cell shape, adhesion, and gene expression. Here we show that natural tooth root topographies induce integrin-mediated extracellular matrix signaling cascades in tandem with cell elongation and polarization to generate physiological periodontium-like tissues. In this study we replanted surface topography instructed periodontal progenitors into rat alveolar bone sockets for 8 and 16 weeks, resulting in complete reattachment of tooth roots to the surrounding alveolar bone with a periodontal fiber apparatus closely matching physiological controls along the entire root surface. Displacement studies and biochemical analyses confirmed that progenitor-based engineered periodontal tissues were similar to control teeth and uniquely derived from preimplantation green fluorescent protein (GFP)-labeled progenitors. Together, these studies illustrate the capacity of natural extracellular surface topographies to instruct progenitor cell populations to fully regenerate complex cellular and structural morphologies of tissues once lost to disease. We suggest that our strategy could be used for the replantation of teeth lost due to trauma or as a novel approach for tooth replacement using tooth-shaped replicas.en
dc.description.sponsorshipStudies were generously supported by the National Institutes of Health Grant DE15045 to T.G.H.D.en
dc.language.isoen_USen
dc.publisherMary Ann Lieberten
dc.subjecthuman periodontal ligamenten
dc.subjectextracellular matrixen
dc.subjectgingival fibroblastsen
dc.subjectnanoscale topographyen
dc.titleApatite Microtopographies Instruct Signaling Tapestries for Progenitor-Driven New Attachment of Teethen
dc.typeArticleen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record