Now showing items 1-2 of 2

    • Bioenergetic shifts during transitions between stem cell states 

      Zhang, Lianghui; Marsboom, Glenn; Glick, Danielle; Zhang, Yanmin; Toth, Peter T.; Jones, Nicole; Malik, Asrar B.; Rehman, Jalees (Pulmonary Circulation, 2014-09-01)
      Two defining characteristics of stem cells are their multilineage differentiation potential (multipotency or pluripotency) and their capacity for self-renewal. Growth factors are well-established regulators of stem cell ...
    • Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4 

      Rehman, Jalees; Marsboom, Glenn (Elsevier (Cell Press), 2016-07-12)
      The molecular mechanisms underlying the regulation of pluripotency by cellular metabolism in human embryonic stem cells (hESCs) are not fully understood. We found that high levels of glutamine metabolism are essential to ...