Now showing items 1-2 of 2

    • Alternative Signaling Pathways as Potential Therapeutic Targets for Overcoming EGFR and c-Met Inhibitor Resistance in Non-Small Cell Lung Cancer 

      Fong, Jason T.; Jacobs, Ryan J.; Moravec, David N.; Uppada, Srijayaprakash B.; Botting, Gregory M.; Nlend, Marie; Puri, Neelu (PLoS One, 2013-11)
      The use of tyrosine kinase inhibitors (TKIs) against EGFR/c-Met in non-small cell lung cancer (NSCLC) has been shown to be effective in increasing patient progression free survival (PFS), but their efficacy is limited due ...
    • Targeting c-Met in melanoma 

      Etnyre, Deven; Stone, Amanda L.; Fong, Jason T.; Jacobs, Ryan J.; Uppada, Srijayaprakash B.; Botting, Gregory M.; Rajanna, Supriya; Moravec, David N.; Chambannagari, Manohar R.; Crees, Zachary; Girard, Jennifer; Bertram, Ceyda; Puri, Neelu (Taylor and Francis, 2014-09)
      Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this ...