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dc.contributor.authorIslam, Abul B. M. M. K.
dc.contributor.authorRichter, William F.
dc.contributor.authorJacobs, Laura A.
dc.contributor.authorLopez-Bigas, Nuria
dc.contributor.authorBenevolenskaya, Elizaveta V.
dc.date.accessioned2012-03-16T16:44:12Z
dc.date.available2012-03-16T16:44:12Z
dc.date.issued2011-08-23
dc.identifier.bibliographicCitationIslam, A. B., Richter, W. F., Jacobs, L. A., Lopez-Bigas, N., & Benevolenskaya, E. V. 2011. Co-regulation of histone-modifying enzymes in cancer. PLoS One, 6(8): e24023. doi:10.1371/journal.pone.0024023en
dc.identifier.issn1932-6203
dc.identifier.otherdoi:10.1371/journal.pone.0024023
dc.identifier.urihttp://hdl.handle.net/10027/8226
dc.descriptionCopyright: 2011 Islam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. doi:10.1371/journal.pone.0024023en
dc.description.abstractCancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes. The epigenetic changes are communicated through chemical modifications, including histone modifications. However, it is unclear whether the binding of histone-modifying proteins to genomic regions and the placing of histone modifications efficiently discriminates corresponding genes from the rest of the genes in the human genome. We performed gene expression analysis of histone demethylases (HDMs) and histone methyltransferases (HMTs), their target genes and genes with relevant histone modifications in normal and tumor tissues. Surprisingly, this analysis revealed the existence of correlations in the expression levels of different HDMs and HMTs. The observed HDM/HMT gene expression signature was specific to particular normal and cancer cell types and highly correlated with target gene expression and the expression of genes with histone modifications. Notably, we observed that trimethylation at lysine 4 and lysine 27 separated preferentially expressed and underexpressed genes, which was strikingly different in cancer cells compared to normal cells. We conclude that changes in coordinated regulation of enzymes executing histone modifications may underlie global epigenetic changes occurring in cancer.en
dc.description.sponsorshipThis project was funded by R01CA138631 (E.V.B.) and grant number 115347-RSG-08-271-01-GMC from the American Cancer Society (E.V.B.). N.L.-B. acknowledges funding from the Spanish Ministry of Science and Education, grant number SAF2009-06954. A.B.M.M.K.I. is supported by a fellowship from AGAUR of the Catalonian Government, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.titleCo-Regulation of Histone-Modifying Enzymes in Canceren
dc.typeArticleen


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