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dc.contributor.authorWardrop, Duncan J.
dc.contributor.authorWaidyarachchi, Samanthi L.
dc.date.accessioned2012-04-29T04:59:24Z
dc.date.available2012-04-29T04:59:24Z
dc.date.issued2010
dc.identifier.bibliographicCitationWardrop, D. J. & Waidyarachchi, S. L. 2010. Synthesis and biological activity of naturally occurring alpha-glucosidase inhibitors. Natural Product Reports, Vol 27 Issue (10): pages 1431-1468. DOI: 10.1039/b914958aen
dc.identifier.issn0265-0568
dc.identifier.otherDOI: 10.1039/b914958a
dc.identifier.urihttp://hdl.handle.net/10027/8280
dc.description© 2010 by Royal Society of Chemistry, Natural Product Reports DOI: 10.1039/b914958aen
dc.description.abstractIn addition to their clinical importance in the treatment of type II diabetes, a-glucosidase inhibitors have attracted considerable attention from the synthetic community because of their profound effect on an array of cellular processes, including N-linked glycoprotein processing and maturation, oligosaccharide metabolism, and cell–cell and cell–virus recognition. Over the past decade, a number of structurally novel naturally occurring a-glucosidase inhibitors which do not conform to the classical iminosugar mold have been identified, including zwitterionic thiosugars and marine organosulfates. While these natural products are important leads in the development of new classes of glucosidase inhibitors, they have also attracted considerable attention as synthetic targets in of themselves. This article reviews the recent literature concerning the synthesis of these emerging natural product families, as well as the preparation of those polyhydroxylated alkaloids more traditionally associated with anti-a-glucosidase activity. 176 references are cited.en
dc.description.sponsorshipUIC and the National Institutes of Health (GM59157) provided financial support.en
dc.language.isoen_USen
dc.publisherRoyal Society of Chemistryen
dc.titleSynthesis and biological activity of naturally occurring a-glucosidase inhibitorsen
dc.typeArticleen


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