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dc.contributor.authorDi, Anke
dc.contributor.authorGao, Xiao‐Pei
dc.contributor.authorQian, Feng
dc.contributor.authorKawamura, Takeshi
dc.contributor.authorHan, Jin
dc.contributor.authorHecquet, Claudie
dc.contributor.authorYe, Richard D
dc.contributor.authorVogel, Stephen M
dc.contributor.authorMalik, Asrar B
dc.date.accessioned2012-08-16T17:51:48Z
dc.date.available2012-08-16T17:51:48Z
dc.date.issued2011
dc.identifier.bibliographicCitationDi, A., Gao, X. P., Qian, F., Kawamura, T., Han, J., Hecquet, C., Ye, R. D., Vogel, S. M., & Malik, A. B. 2011. The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nature Immunology, 13(1): 29-34. doi:10.1038/ni.2171en
dc.identifier.issn1529-2908
dc.identifier.otherdoi:10.1038/ni.2171
dc.identifier.urihttp://hdl.handle.net/10027/8490
dc.description© 2011 by Nature Publishing Group, Nature Immunology doi:10.1038/ni.2171en
dc.description.abstractThe NADPH oxidase activity of phagocytes and its generation of reactive oxygen species (ROS) is critical for host‐defense, but ROS overproduction can also lead to inflammation and tissue injury. Here we report that TRPM2, a nonselective and redox‐sensitive cation channel, inhibited ROS production in phagocytic cells and prevented endotoxin‐induced lung inflammation in mice. TRPM2‐deficient mice challenged with endotoxin (lipopolysaccharide) showed an enhanced inflammatory response and lower survival relative to that of wild‐type mice challenged with endotoxin. TRPM2 functioned by dampening NADPH oxidase–mediated ROS production through depolarization of the plasma membrane in phagocytes. As ROS also activate TRPM2, our findings establish a negative feedback mechanism for the inactivation of ROS production through inhibition of the membrane potential–sensitive NADPH oxidase.en
dc.description.sponsorshipSupported by the Francis Families Foundation (Parker B. Francis Fellowship Program, 2007−2010) and the US National Institutes of Health (P01 HL77806).en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.titleThe redox‐sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammationen
dc.typeArticleen


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