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dc.contributor.authorGandra, Sumanth
dc.contributor.authorScott, William S.
dc.contributor.authorSomaraju, Vijaya
dc.contributor.authorWang, Huaping
dc.contributor.authorWilton, Suzanne
dc.contributor.authorFeigenbaum, Michelle
dc.date.accessioned2012-08-17T19:20:37Z
dc.date.available2012-08-17T19:20:37Z
dc.date.issued2010-12
dc.identifier.bibliographicCitationGandra, S., Scott, W. S., Somaraju, V., Wang, H., Wilton, S., & Feigenbaum, M. 2010. Questionable effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a screening tool in healthcare workers. Journal of Clinical Endocrinology and Metabolism, 31(12): 1279-1285. DOI: 10.1086/657336en
dc.identifier.issn0021-972X
dc.identifier.otherDOI: 10.1086/657336
dc.identifier.urihttp://hdl.handle.net/10027/8536
dc.description© 2011 by Endocrine Society, Journal of Clinical Endocrinology and Metabolism DOI: 10.1086/657336en
dc.description.abstractobjective. The Center for Disease Control and Prevention recommends the use of QuantiFERON TB Gold test (QFTG; Cellestis) in all situations where the tuberculin skin test (TST) is used. In November 2007, our institution replaced its screening-tool TST with the QFTG in-tube assay (QFT-GIT) for annual screening of latent tuberculosis infection among healthcare workers (HCWs). This study evaluated the effectiveness of QFT-GIT test as screening tool in HCWs at our institution. methods. This retrospective study reviewed medical records of all HCWs who underwent screening with QFT-GIT from January 2008 through December 2008. results. Among the 6,530 HCWs screened with QFT-GIT from January through December 2008, 287 had a positive test result. Of the 287, 123 had positive TST results in the past, meaning that 164 HCWs had newly diagnosed latent tuberculosis infection by QFT-GIT. Of the 164 HCWs, 135 were retested by QFT-GIT and were simultaneously tested with TST within 4 weeks after the initial QFT-GIT. Of these 135 HCWs, 66 reverted to negative results and results remained positive for 69 with QFT-GIT. Only 2 HCWs had a positive TST result. conclusions. The disagreement between QFT-GIT and TST results and the high reversion rate with QFT-GIT raise concerns about the effectiveness of QFT-GIT as a sole screening test in HCWs.en
dc.language.isoen_USen
dc.publisherEndocrine Societyen
dc.titleQuestionable Effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a Screening Tool in Healthcare Workersen
dc.typeArticleen


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