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dc.contributor.authorShen, Hao
dc.contributor.authorHong, Seungpyo
dc.contributor.authorPrud'homme, Robert
dc.contributor.authorLiu, Ying
dc.date.accessioned2012-08-18T03:23:18Z
dc.date.available2012-08-18T03:23:18Z
dc.date.issued2011-09
dc.identifier.bibliographicCitationShen, H., Hong, S. Y., Prud'homme, R. K., & Liu, Y. 2011. Self-assembling process of flash nanoprecipitation in a multi-inlet vortex mixer to produce drug-loaded polymeric nanoparticles. Journal of Nanoparticle Research, 13(9): 4109-4120. DOI: 10.1007/s11051-011-0354-7.en
dc.identifier.issn1388-0764
dc.identifier.otherDOI: 10.1007/s11051-011-0354-7
dc.identifier.urihttp://hdl.handle.net/10027/8552
dc.descriptionPost print version of article may differ from published version. The original publication is available at springerlink.com; DOI: 10.1007/s11051-011-0354-7.en
dc.description.abstractWe present an experimental study of self-assembled polymeric nanoparticles in the process of flash nanoprecipitation using a multi-inlet vortex mixer (MIVM). beta-Carotene and polyethyleneimine (PEI) are used as a model drug and a macromolecule, respectively, and encapsulated in diblock copolymers. Flow patterns in the MIVM are microscopically visualized by mixing iron nitrate (Fe(NO(3))(3)) and potassium thiocyanate (KSCN) to precipitate Fe(SCN) (x) ((3-x)+) . Effects of physical parameters, including Reynolds number, supersaturation rate, interaction force, and drug-loading rate, on size distribution of the nanoparticle suspensions are investigated. It is critical for the nanoprecipitation process to have a short mixing time, so that the solvent replacement starts homogeneously in the reactor. The properties of the nanoparticles depend on the competitive kinetics of polymer aggregation and organic solute nucleation and growth. We report the existence of a threshold Reynolds number over which nanoparticle sizes become independent of mixing. A similar value of the threshold Reynolds number is confirmed by independent measurements of particle size, flow-pattern visualization, and our previous numerical simulation along with experimental study of competitive reactions in the MIVM.en
dc.language.isoen_USen
dc.publisherSpringer Verlagen
dc.subjectcanceren
dc.subjectnanoparticlesen
dc.titleSelf-assembling process of flash nanoprecipitation in a multi-inlet vortex mixer to produce drug-loaded polymeric nanoparticlesen
dc.typeArticleen


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