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Prevention of Estrogen Carcinogenesis by Botanicals, SERMs and NO/cGMP Pathway Modulators
The risk of developing hormone dependent cancers in women will increase with long term exposure to estrogens. Estrogen induced cell proliferation in estrogen receptor positive cells (hormonal pathway) and formation of ...
Novel Approaches to Endocrine Therapy in Endocrine-Independent Breast Cancer
Tamoxifen, an antagonist at estrogen receptor alpha (ERα) in breast tissue, and the prototypical selective estrogen receptor modulator (SERM), is the standard of care for many patients with ER-positive breast cancer. ...
Novel Strategy for Treating Estrogen Receptor Positive Advanced Breast Cancer
Approximately 70% of breast cancer patients are estrogen receptor positive (ER+). Aromatase inhibitors and the selective estrogen receptor modulator (SERM), tamoxifen, are the first line treatments for these patients; ...
Estrogenic And Chemopreventive Properties of Licorice Species Used For Menopausal Symptoms
Hormone therapy (HT) has been the most efficacious treatment for relieving menopausal symptoms. However, Women’s Health Initiative showed an increased breast cancer risk associated with HT. Therefore, menopausal women have ...