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Hormonal Regulation of CYP2B6 and CYP2D6 Expression
Purpose: Despite clinical observations of altered drug metabolism during pregnancy, little is known about the underlying molecular mechanism. Differential hepatic metabolism during pregnancy results in altered plasma ...
Molecular Basis of Inter-Individual Variability in Cytochrome P450 2D6-Mediated Drug Metabolism
Cytochrome P450 (CYP) 2D6 is a major drug-metabolizing enzyme, eliminating over 20% of clinically used drugs. CYP2D6-mediated drug metabolism exhibits large inter-individual variability. Genetic polymorphisms of CYP2D6 are ...
Effects of Fenofibrate on CYP2D6 and Regulation of ANG1 and RNASE4 by the FXR Agonist Obeticholic Acid
CYP2D6 is a major drug metabolizing enzyme that exhibits large interindividual variability, in part due to differential transcriptional regulation of CYP2D6; however, the factors controlling transcriptional regulation of ...
Transcriptional Regulation of Cytochrome P450 2D6 by Small Heterodimer Partner
Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme, responsible for eliminating ~20% of marketed drugs. Of note, CYP2D6 activity exhibits large interindividual variability, but the factors leading to this ...