Now showing items 1-4 of 4
Dinitrosyl Iron Complexes and their Role in Patho-physiological Conditions
Nitric oxide (•NO) is a small free radical known to play an important role in cancer. Inside the cell, one of its primary interactions occurs with iron and thiols leading to the formation of dinitrosyl iron complexes (DNIC). ...
A Multi-Scale Hybrid Nanoparticle Platform with Controlled Cellular Interaction and Targeting Kinetics
Polymeric nanoparticles (NPs) and dendrimers are two major classes of nanomaterials that have demonstrated great potential for targeted drug delivery. However, they each have drawbacks such as limited tissue diffusivity/tumor ...
Natural Product Anticancer Drug Discovery and Mechanistic Studies on Hapolosin and Silvestrol
Cancer is one of the major health concerns for people and will be for the foreseeable future. Chemotherapy, as well as surgery and radiation, is an important clinical method to successfully treat cancer. Within the ...
Molecular Mechanism of Src Regulation by Csk, SHP-2, Cbp, and Caveolin-1
Aaron T. Place, Ph.D. Department of Pharmacology University of Illinois at Chicago Chicago, Illinois (2011) Dissertation Chairperson: Richard D. Minshall Ph.D. The exact molecular details of Src family kinase activation ...