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The Novel Modes of Action of Ribosomal Antibiotics
Ribosome, a macromolecular machine that synthesizes proteins inside all living cells, is one of the biggest targets for small molecules called antibiotics. Several antibiotics, commonly used to treat bacterial infections, ...
Nascent Peptide and Small Molecule Mediated Translation Regulation
The goal of this work was to investigate how the interplay of the nascent peptide with the small molecule cofactors modulates ribosome function and as a consequence regulate gene expression in a cell. To study this we used ...