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The Novel Modes of Action of Ribosomal Antibiotics
Ribosome, a macromolecular machine that synthesizes proteins inside all living cells, is one of the biggest targets for small molecules called antibiotics. Several antibiotics, commonly used to treat bacterial infections, ...
Functional Interactions Between Ribosome and Nascent Peptide Mediated By Small Molecules
Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic resistance genes, activated by binding of macrolide drugs to the ...
Nascent Peptide and Small Molecule Mediated Translation Regulation
The goal of this work was to investigate how the interplay of the nascent peptide with the small molecule cofactors modulates ribosome function and as a consequence regulate gene expression in a cell. To study this we used ...
Chloramphenicol and Linezolid Selectively Trap A-Site tRNAs in the Ribosome
Abstract The ribosome makes all the proteins in the cell by adding amino acids to the protein chain one by one. The amino acids are delivered to the so-called A site of the functional center of the ribosome by special ...