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Modulation of Estrogen Metabolism by Hops Extracts and Bioactive Compounds as Analyzed by LC-MS-MS
The oxidative metabolism of estrogens into estrogen quinones that damage DNA, contributes to the carcinogenicity of estrogens. In order to circumvent using hormone replacement therapy, many women in the United States use ...
Protein Kinase C Alpha Destabilizes Adherens Junctions via p120-Catenin in Human Breast Cancer
Breast cancer is the most common type of cancer in women and progression to metastatic disease, often accompanied by drug resistance, greatly reduces a woman’s chance for survival. Metastasis is the spread and growth of ...
Selective Estrogen Mimics for the Treatment of Tamoxifen-Resistant, PKCalpha-Overexpressing Breast Cancer
Breast cancer is the most common female malignancy, affecting 1 in 8 women. Resistance to the antiestrogen tamoxifen (TAM), whether de novo or acquired, is a major clinical obstacle. Although recent clinical trials have ...
Interactions of Dendritic Nanomaterials with Skin Layers and Their Applications in Topical Drug Delivery
The barrier functions of the stratum corneum and the epidermal layers present a tremendous challenge in achieving effective transdermal delivery of drug molecules. Among many nanocarriers that have been tested to improve ...