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Hormonal Regulation of Hepatic CYP Expression: Implications in Altered Drug Metabolism during Pregnancy
Pregnancy alters hepatic drug metabolism in a cytochrome P450 (CYP) isoform-specific manner, and rising concentrations of female hormones are potentially responsible for the changes. The objective of this study is to ...
Hormonal Regulation of CYP2B6 and CYP2D6 Expression
Purpose: Despite clinical observations of altered drug metabolism during pregnancy, little is known about the underlying molecular mechanism. Differential hepatic metabolism during pregnancy results in altered plasma ...
Molecular Basis of Inter-Individual Variability in Cytochrome P450 2D6-Mediated Drug Metabolism
Cytochrome P450 (CYP) 2D6 is a major drug-metabolizing enzyme, eliminating over 20% of clinically used drugs. CYP2D6-mediated drug metabolism exhibits large inter-individual variability. Genetic polymorphisms of CYP2D6 are ...
Transcriptional Regulation of Cytochrome P450 2D6 by Small Heterodimer Partner
Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme, responsible for eliminating ~20% of marketed drugs. Of note, CYP2D6 activity exhibits large interindividual variability, but the factors leading to this ...