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The Influence of Two CYP2C9 Promoter SNPs on CYP2C9 Expression and Caffeine’s Impact on CYP1A2
The R150H polymorphism—the most common in African Americans—is associated with decreased S-warfarin clearance and as a result lower warfarin dose requirements. CYP2C9 R150H was found to be in strong linkage disequilibrium ...
Patient Outcomes with Warfarin Therapy after Hip and Knee Replacement: Comparison of Two Models of Care
The first objective of the study was to examine the association between race of the patients and their referral to anticoagulation clinic compared to orthopedic clinic for venous thromboembolism prophylaxis (VTE) post-surgery. ...
Drug Metabolism in Early Stage Drug Discovery and Drug Development
Drug metabolism is an essential element in drug discovery and development process by interacting with multiple disciplines, including medicinal chemistry, pharmacology, preclinical development, clinical development, safety ...
Navigating Safety of Anticoagulant Use From Precision Medicine to Direct Oral Anticoagulants
Background: This dissertation focuses on assessing avenues for safe delivery of oral anticoagulants. In that, three studies have been undertaken to address gaps in practice pertaining to Vitamin K Antagonist (VKA) and ...