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Molecular Basis of Inter-Individual Variability in Cytochrome P450 2D6-Mediated Drug Metabolism
Cytochrome P450 (CYP) 2D6 is a major drug-metabolizing enzyme, eliminating over 20% of clinically used drugs. CYP2D6-mediated drug metabolism exhibits large inter-individual variability. Genetic polymorphisms of CYP2D6 are ...
Effects of Fenofibrate on CYP2D6 and Regulation of ANG1 and RNASE4 by the FXR Agonist Obeticholic Acid
CYP2D6 is a major drug metabolizing enzyme that exhibits large interindividual variability, in part due to differential transcriptional regulation of CYP2D6; however, the factors controlling transcriptional regulation of ...