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  • Molecular evolution of a-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization 

    Johnson, Keven R.; Nicodemus-Johnson, Jessie; Carnegie, Graeme K.; Danziger, Robert S. (BioMed Central, 2012-07)
    Background: A-Kinase Anchoring Proteins (AKAPs) are molecular scaffolding proteins mediating the assembly of multi-protein complexes containing cAMP-dependent protein kinase A (PKA), directing the kinase in discrete ...
  • Peripheral Blood Gene Expression as a Novel Genomic Biomarker in Complicated Sarcoidosis 

    Zhou, Tong; Zhang, Wei; Sweiss, Nadera J.; Chen, Edward S.; Moller, David R.; Knox, Kenneth S.; Ma, Shwu-Fan; Wade, Michael S.; Noth, Imre; Machado, Roberto F.; Garcia, Joe G. N. (Public Library of Science, 2012-09)
    Sarcoidosis, a systemic granulomatous syndrome invariably affecting the lung, typically spontaneously remits but in ,20% of cases progresses with severe lung dysfunction or cardiac and neurologic involvement (complicated ...
  • Genetic Associations in the Vitamin D Receptor and Colorectal Cancer in African Americans and Caucasians 

    Kupfer, Sonia S.; Anderson, Jeffrey R.; Ludvik, Anton E.; Hooker, Stanley; Skol, Andrew; Kittles, Rick A.; Keku, Temitope O.; Sandler, Robert S.; Ruiz-Ponte, Clara; Castellvi-Bel, Sergi; Castells, Antoni; Carracedo, Angel; Ellis, Nathan A. (Public Library of Science, 2011-10-27)
    Low vitamin D levels are associated with an increased incidence of colorectal cancer (CRC) and higher mortality from the disease. In the US, African Americans (AAs) have the highest CRC incidence and mortality and the ...
  • Linkage of Type I Interferon Activity and TNF-Alpha Levels in Serum with Sarcoidosis Manifestations and Ancestry 

    Sweiss, Nadera J.; Zhang, Wei; Franek, Beverly S.; Kariuki, Silvia N.; Moller, David R.; Patterson, Karen C.; Bennett, Peggy; Girijala, Lakshmi R.; Nair, Vaisak; Baughman, Robert P.; Garcia, Joe G. N.; Niewold, Timothy B. (Public Library of Science, 2011-12-14)
    Background: Both type I interferon (IFN), also known as IFN-a and tumor necrosis factor alpha (TNF-a) have been implicated in the pathogenesis of sarcoidosis. We investigated serum levels of these cytokines in a large ...
  • Bioinformatic resources of microRNA sequences, gene targets, and genetic variation 

    Mu, Wenbo; Zhang, Wei (Frontiers Research Foundation, 2012)
    Variation in quantitative gene expression has been observed in natural populations and associated with various complex traits/phenotypes such as risks for common diseases and drug response. MicroRNAs (miRNAs), a family ...