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T*
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T*
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T*
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[(nt)-6.2(agonists)-420.7(decreased)-419.5(c)-4.6(lini)-6.2(c)1.7(al)]TJ
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[(meas)5.2(ures)-424.8(of)-426.2(both)-429.9(s)5.2(trength)-423.6(a)-2.4(nd)-423.6(sp)]TJ
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[(as)-4.6(tici)-7.4(t)-1.1(y/s)-4.6(p)-3.4(as)-4.6(ms)-4.6(,)-430.4(w)-.4(her)-6(eas)-434.5(a)-5.8(d)2.9(-)]TJ
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[(min)7.2(i)-3.1(s)6.1(t)3.2(ra)4.8(tion)-523.9(o)7.2(f)-520.2(SSRIs)-518.7(au)7.2(gm)3.7(en)7.2(ted)-517.6(both)-517.6(b).9(eh)7.2(av)7.2(io)7.2(rs)6.1(.)-521(A)-2.4(c)4.8(u).9(te)-520(ad)7.2(-)]TJ
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[(m)-4.9(i).9(ni)-5.4(stration)-437.7(o)-1.4(f)-440.3(e)2.5(ither)-433.9(m)-4.9(e)2.5(dication)-437.7(a)2.5(ppears)-438.9(t).9(o)-444(b)4.9(e)-440.1(i).9(neffective)-440.1(a)2.5(t)]TJ
T*
.0174 Tc
[(imp)5.2(r)-3.7(ov)5.2(ing)-380.5(l)1.2(ocomoto)5.2(r)-383.1(function.)]TJ
/F10 1 Tf
0 -3.0603 TD
0 Tc
[(Serotonergic)-338.5(modulation)-335.5(of)-330.4(motor)-338.6(output)]TJ
/F4 1 Tf
1.1128 -1.8273 TD
[(The)-266.3(nding)-258.9(that)-267.7(volitional)-264.2(strength)-263.3(and)-260.2(spastic)-271.1(motor)-260.6(behaviors)]TJ
-1.1128 -1.2266 TD
[(covary)-301.7(following)-298.1(different)-300.8(SSRI)-299.7(medication)-296.2(is)-301.4(of)-298.8(primary)-296.3(interest)]TJ
0 -1.2203 TD
[(in)-230.7(the)-226.3(current)-225.6(study.)-227(In)-229.3(addition,)-228.5(signicant)-226.8(correlations)-228.5(in)-230.7(baseline)]TJ
T*
[(clinical)-221.8(measures)-214.2(of)-216.6(strength)-212.7(and)-215.9(spasticity)-214.4(\(mAsh\),)-215.6(but)-211.2(not)-217.5(spasms)]TJ
0 -1.2266 TD
[(\(SCATS\),)-509.2(were)-508.3(observed.)-500.8(Although)-507(difculties)-504.8(exist)-508.7(in)-502.6(distin-)]TJ
0 -1.2203 TD
[(guishing)-429(voluntary)-426(versus)-421.8(involuntary)-429(contractions)-428.2(with)-426.7(clinical)]TJ
T*
[(measures,)-223.4(the)-220(combined)-223.5(ndings)-221.7(are)-221(consistent)-223(with)-218(the)-220(hypothesis)]TJ
0 -1.2266 TD
[(that)-305.7(common)-303.7(neural)-305.7(pathways)-306.6(underlie)-302.4(selected)-305.8(voluntary)-305.9(and)-304.5(in-)]TJ
0 -1.2203 TD
[(voluntary)-293.2(behaviors.)-295.7(Potential)-293.3(mechanisms)-294(underlying)-292.7(such)-292.5(chan-)]TJ
T*
[(ges)-349.9(include)-344.6(modulation)-348.2(of)-343.1(passive)-349.3(and)-348.7(active)-347.5(\(PIC\))-343.8(properties)-349.5(of)]TJ
0 -1.2266 TD
[(spinal)-305.9(moto-)-298.6(and)-298.1(interneurons,)-307.2(in)-300.2(addition)-301.4(to)-300.2(separate)-304.4(modulatory)]TJ
0 -1.2203 TD
[(effects)-197.6(on)-182.4(afferent)-192.2(and)-190.6(descending)-190.9(pathways.)-189.4(The)-190.5(coupling)-189.9(of)-185(reex)]TJ
T*
[(and)-336.1(volitional)-327.5(motor)-330.2(output)-333.9(may)-333.3(also)-328.1(be)-330.2(seen)-332.9(during)-332.5(quantitative)]TJ
T*
[(assessments,)-252.2(as)-242.9(reex)-250.2(activity)-244.6(in)-249.6(individuals)-241.9(with)-249.7(SCI)-244.7(can)-243.6(strongly)]TJ
0 -1.2266 TD
[(inuence)-284.2(static)-287(and)-279.2(dynamic)-280.9(volitional)-283.2(behaviors.)]TJ
6.7246 0 0 5.9768 493.3416 170.8724 Tm
(10)Tj
8.9663 0 0 8.9663 323.0361 155.9055 Tm
[(Changes)-203.3(in)-199.1(strength)-200(and)-197(reex)-205.9(activity)-200.4(were)-198.5(relatively)-204.4(consistent)]TJ
-1.1128 -1.2203 TD
[(following)-298.1(either)-297.1(medication,)-292.8(with)-293.9(few)-297.7(outliers)-292.6(from)-297.6(different)-294.5(sub-)]TJ
0 -1.2266 TD
[(jects)-258.2(on)-251.9(separate)-253.8(testing)-258.8(days,)-251.2(\(see)-253.3(Fig.)-250.7(2\).)-257.5(However,)-253.8(a)-254.8(rather)-251.4(large)]TJ
0 -1.2203 TD
[(increase)-323.4(in)-312.9(SCATS)-318.7(values)-316.9(was)-321.6(observed)-314.5(following)-317.1(SSRI)-318.7(medica-)]TJ
T*
[(tion)-259(\(Fig.)-265.4(1F\).)-255.6(This)-262.3(behavior)-260.5(may)-257.4(be)-260.7(related)-261.1(to)-256(the)-264.2(time-dependent)]TJ
0 -1.2266 TD
[(assessment)-495.2(of)-488.5(extensor)-489.3(and)-487.8(clonic)-490.5(spasms)-487.1(in)-489.9(the)-485.5(SCATS,)-492.3(and)]TJ
0 -1.2203 TD
[(suggests)-290.6(that)-286.7(increased)-291.3(persistence)-289.2(of)-286.2(spasms)-291.1(with)-287.6(SSRIs)-287.8(may)-289(ac-)]TJ
T*
[(count)-193.7(for)-187.1(the)-194.7(large)-186.1(differences.)-197.3(Despite)-191(this)-190.6(observation,)-191.3(the)-188.3(general)]TJ
T*
[(correlations)-329.7(between)-321(medication-induced)-322.7(changes)-327.5(in)-319.2(strength)-320.2(and)]TJ
0 -1.2267 TD
[(spasticity/spasms)-287.8(were)-280.7(observed.)]TJ
ET
q
490.479 0 0 222.463 62.022 509.783 cm
/Im1 Do
Q
BT
/F6 1 Tf
8.9663 0 0 8.9663 62.022 493.0014 Tm
[(FIG.)-284.2(1.)]TJ
/F4 1 Tf
4.0593 0 TD
[(Assessments)-288.1(of)-279.8(volitional)-283.2(and)-279.2(reexive)-286.8(motor)-279.6(behaviors)-280.1(following)-285.5(administration)-278.3(of)-286.2(serotonergic)-281.4(medication)-283.5(in)-281.3(patients)-279.7(with)]TJ
-4.0593 -1.1065 TD
[(motor)-412.4(incomplete)-410(spinal)-413.4(cord)-414.1(injury)-406.1(\(SCI\).)-416.3(\()]TJ
/F6 1 Tf
18.6968 0 TD
(AC)Tj
/F4 1 Tf
1.9411 0 TD
[(\))-406.8(Median)-417.6(Lower)-410.4(Extremity)-414.4(Motor)-409.5(Score)-408.2(\(LEMS\),)-415.1(modied)-409.8(Ashworth)-415.2(assessment)]TJ
-20.638 -1.1128 TD
[(\(mAsh\))-332.8(and)-323.4(Spinal)-328.6(Cord)-327.8(Assessment)-331.7(Tools)-331.4(for)-326.2(Spastic)-331.7(Reexes)-330.8(\(SCATS\))-329.3(scores)-329.4(are)-334.8(shown)-324.5(during)-332.5(baseline)-328.7(conditions)-326.9(and)-329.7(following)]TJ
T*
[(either)-366.6(serotonin)-357.6(\(5-HT\)-agonist)-366.1(\(8)-166(mg)-363(cyproheptadine\))-363.4(or)-362(a)-362.3(selective)-366.3(5-HT)-357.9(reuptake)-364.1(inhibitor)-362(\(SSRI\))-367.2(\(10)-165.5(mg)-363(escitalopram\).)-363.3(\()]TJ
/F6 1 Tf
51.4242 0 TD
(DF)Tj
/F4 1 Tf
1.8273 0 TD
.3625 Tc
(\)A)Tj
-53.2516 -1.1065 TD
0 Tc
[(median)-275(change)-276.2(of)-273.5(1.253.5)-274.8(is)-269.8(observed)-276.6(when)-275.7(individual)-272.9(change)-276.2(scores)-278.8(are)-277.9(assessed.)-276.6(Dashed)-272(line)-274.1(indicates)-281.7(no)-270.9(change)-276.2(from)-272.4(baseline)-278.1(and)]TJ
0 -1.1128 TD
[(is)-333(provided)-333.9(for)-332.5(visual)-337.5(reference.)-340.9(*)]TJ
/F8 1 Tf
13.9483 0 TD
(p)Tj
/F5 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.05;)-333.8(**)]TJ
/F8 1 Tf
3.3638 0 TD
(p)Tj
/F5 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
(0.01.)Tj
/F1 1 Tf
-20.0816 34.1753 TD
(500)Tj
41.7439 0 TD
[(THOMPSON)-337.3(AND)-330.9(HORNBY)]TJ
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