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[(studies)-282.8(suggest)-285.1(decreased)-278.4(connectivity)-286.7(in)-278.8(amygdala)-277(and)-284.1(cor-)]TJ
0 -1.2266 TD
[(tico-limbic)-208.1(circuits)-199.2(involved)-207.3(in)-202.9(mood)-202.1(regulation)-202.9(in)-202.9(BD)-200.4(relative)]TJ
0 -1.2203 TD
[(to)-806.3(HC.)-806.1(Furthermore,)-811.5(using)-804.4(dynamic)-807.4(causal)-801.2(modeling,)]TJ
T*
[(Almeida)-242.4(and)-239.8(associates)-242.9(\(2009\))-245.6(found)-244.9(evidence)-243.6(of)-237.2(dysfunction)]TJ
0 -1.2266 TD
[(in)-354.7(ventromedial)-362.8(systems)-360.4(involved)-359(in)-354.7(stimulus)-364.5(evaluation)-356.2(in)]TJ
0 -1.2203 TD
[(BD.)-374(To)-366.2(date,)-372.5(there)-371.1(are)-373.2(only)-374.5(two)-371.6(published)-369.6(studies)-377.6(on)-372.9(func-)]TJ
T*
[(tional)-373.6(connectivity)-381.6(in)-373.6(pediatric)-371.7(population)-380.5(with)-375.7(BD)-371.1(relative)]TJ
0 -1.2266 TD
[(to)-370(HC,)-369.8(and)-372.6(they)-368.6(suggest)-373.6(altered)-373.7(functional)-371.8(connectivity)-375.3(be-)]TJ
0 -1.2203 TD
[(tween)-239.2(limbic)-233.2(and)-227.2(temporal)-239.8(regions)-237.3(during)-231.4(face)-233.1(emotion)-238(iden-)]TJ
T*
[(tication)-534.4(\(Rich)-535.7(et)-537.8(al.,)-533.7(2008\))-529.6(and)-537(between)-534.4(the)-534.9(frontal)-535.6(and)]TJ
T*
[(temporal)-511.6(circuit)-514(during)-509.6(the)-515.9(resting)-513.2(state)-507.5(\(Dickstein)-517.2(et)-512.5(al.,)]TJ
0 -1.2266 TD
[(2010\).)-311.3(However,)-312(so)-307.6(far,)-313.4(no)-309.7(study)-307.7(has)-314(investigated)-311(functional)]TJ
0 -1.2203 TD
[(connectivity)-457.5(in)-455.8(PBD)-448.4(in)-455.8(a)-448.4(task)-454.6(at)-448.9(the)-459(interface)-456.1(of)-452.2(cognitive)]TJ
T*
[(and)-492.8(affective)-491.1(systems.)-496.1(To)-492.6(our)-491.7(knowledge,)-487.4(this)-495.6(is)-491.7(the)-490.6(rst)]TJ
27.9978 74.5535 TD
[(whole-brain)-687.1(functional)-681.6(connectivity)-685.1(study)-680.8(conducted)-682.7(on)]TJ
0 -1.2203 TD
[(functional)-409.7(networks)-400.3(underlying)-407(the)-402.1(interaction)-402.6(between)-407.9(af-)]TJ
T*
[(fective)-307.8(and)-303.1(working)-299.1(memory)-300.1(systems)-303.5(in)-304.1(PBD.)]TJ
1.1128 -1.2267 TD
[(Based)-373.5(on)-366.6(the)-376.8(initial)-371.6(indications)-371.5(of)-370(altered)-373.7(functional)-371.8(con-)]TJ
-1.1128 -1.2203 TD
[(nectivity)-325.6(in)-316.7(PBD,)-318.5(we)-317.7(used)-321.7(a)-315.7(well-established)-320.2(functional)-321.2(con-)]TJ
T*
[(nectivity)-565.8(method,)-560.1(independent)-565(component)-567.3(analysis)-560.3(\(ICA\))]TJ
0 -1.2266 TD
[(\(Calhoun)-305.4(et)-303.9(al.,)-299.7(2001;)-298.1(Stevens)-307.7(et)-303.9(al.,)-299.7(2007,)-298.1(2009\),)-304.9(to)-300.4(study)-301.4(the)]TJ
0 -1.2203 TD
[(differences)-403.9(between)-395.3(PBD)-397.8(and)-391.6(HC)-392.2(in)-398.9(large-scale)-391.4(distributed)]TJ
T*
[(neural)-229.7(network)-221.9(connectivity.)-232.7(The)-221.3(advantages)-226.7(of)-224.5(ICA)-225(method-)]TJ
T*
[(ology)-334.1(include)-330.1(that)-332.6(unlike)-332.3(typical)-334.6(fMRI)-334.4(analyses,)-332(ICA)-326.1(identi-)]TJ
0 -1.2266 TD
[(es)-1041.2(spatially)-1041.5(independent)-1045.5(components)-1042.8(within)-1040.2(blood)]TJ
0 -1.2203 TD
[(oxygenation)-450.4(level-dependent)-458.7(\(BOLD\))-447.7(time)-444.1(series)-449.3(data)-445.1(in)-449.5(a)]TJ
T*
[(data-driven)-437.9(manner,)-437.3(without)-430.9(the)-433.7(need)-436.1(for)-433.9(a)-429.5(task)-435.7(reference)]TJ
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[(function)-349.8(to)-344.7(separate)-344.1(signal)-344.5(from)-342.9(noise)-346(\(Calhoun)-343.4(et)-341.8(al.,)-344(2001;)]TJ
0 -1.2203 TD
[(Stevens)-516.3(et)-512.5(al.,)-508.4(2007,)-506.8(2009\).)-507.3(Participants)-513.9(performed)-512.2(a)-505.3(two-)]TJ
T*
[(back)-210(affective)-212.9(working)-210.5(memory)-205.3(task,)-211(which)-213.6(typically)-209.8(engages)]TJ
0 -1.2266 TD
[(fronto-striato-parietal)-477.7(networks)-469.8(\(Owen)-463.7(et)-468.3(al.,)-464.1(2005\),)-463(where)]TJ
0 -1.2203 TD
[(stimuli)-491.9(were)-495.3(angry)-486.7(and)-492.8(neutral)-489.4(faces.)-490.3(For)-488.4(the)-490.6(purpose)-495.6(of)]TJ
T*
[(this)-407(study,)-399.2(we)-399.9(focused)-406.4(on)-404.5(negative-valence)-404.3(stimuli)-403.3(such)-403.7(as)]TJ
0 -1.2266 TD
[(angry)-549.9(faces,)-553.5(rather)-548.4(than)-550.5(positive-valence)-557.8(stimuli,)-545.3(because)]TJ
0 -1.2203 TD
[(negative-valence)-239.9(stimuli)-232.6(have)-224.8(been)-235.2(more)-228.6(effective)-232.3(in)-228.2(identify-)]TJ
T*
[(ing)-384.4(neural)-387.8(markers)-383.5(of)-382.6(manic)-382.7(state)-381(in)-386.3(PBD)-378.8(\(Passarotti)-390.8(et)-379.7(al.,)]TJ
T*
[(2010a,)-304(2010c,)-297.4(2011;)-298.1(Pavuluri)-302.9(et)-303.9(al.,)-299.7(2008\).)]TJ
1.1128 -1.2266 TD
[(We)-232.9(hypothesized)-237.9(that)-231.5(the)-231.4(data-driven)-235.5(ICA)-231.3(analyses)-234.2(would)]TJ
-1.1128 -1.2203 TD
[(reveal)-352(functionally)-354.4(segregated)-355(networks)-349.7(related)-354.8(to)-351(face)-346.9(pro-)]TJ
T*
[(cessing,)-306.9(working)-305.4(memory,)-303(and)-303.1(affect)-303.6(processing)-302.5(and)-303.1(regula-)]TJ
0 -1.2266 TD
[(tion,)-1359.9(encompassing)-1358.2(regions)-1356.5(found)-1351.4(with)-1355.8(previous)]TJ
0 -1.2203 TD
[(conventional)-338.8(fMRI)-334.4(studies)-333.4(using)-336.5(similar)-332.2(paradigms,)-330(such)-334.1(as)]TJ
T*
[(an)-319(emotion)-320.2(processing)-321.5(network)-316.8(\(i.e.,)-316.1(amygdala\),)-318.4(an)-319(emotion)]TJ
0 -1.2266 TD
[(evaluation)-438.4(network)-436.9(\(including)-443.2(medial)-430.7(PFC)-435.9(and)-435.9(insula\),)-433.3(an)]TJ
0 -1.2203 TD
[(emotion)-415.1(regulation)-411.6(network)-405.3(\(including)-411.6(VLPFC)-410.1(and)-410.6(ventral)]TJ
T*
[(ACC\))-508(\(Foland)-510.3(et)-506.2(al.,)-508.4(2008;)-506.8(Passarotti)-510.5(et)-506.2(al.,)-508.4(2010a,)-506.3(2010b;)]TJ
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[(Pavuluri)-220.8(et)-221.7(al.,)-217.5(2008\),)-216.4(a)-214.5(Working)-220.6(Memory)-219.1(Network,)-221.4(including)]TJ
0 -1.2203 TD
[(fronto-striatal)-431.1(circuits)-420.5(\(DEsposito,)-427.9(2007;)-418.3(Owen)-418.9(et)-417.7(al.,)-419.9(2005;)]TJ
T*
[(Passarotti)-263.9(et)-259.6(al.,)-255.5(2010a,)-253.4(2010c\),)-260(and)-258.8(a)-252.4(face)-258.4(processing)-264.6(network)]TJ
T*
[(\(Haxby)-314.5(et)-310.2(al.,)-312.4(2002;)-310.8(Passarotti)-314.5(et)-316.5(al.,)-306.1(2007\).)-311.3(We)-315.1(hypothesized)]TJ
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[(that)-339(PBD)-340.9(patients)-338.7(relative)-337.1(to)-338.4(HC)-335.3(would)-334.8(show)-337.9(differences)-340.6(in)]TJ
0 -1.2203 TD
[(regional)-340.2(functional)-346.5(connectivity)-343.6(in)-335.7(these)-340.1(brain)-340.3(networks,)-340(es-)]TJ
T*
[(pecially)-337.5(in)-342(regions)-338.5(involved)-333.8(in)-335.7(emotion)-339.2(processing,)-343.4(emotion)]TJ
0 -1.2266 TD
[(evaluation,)-605.7(and)-606.6(emotion)-604.8(regulation,)-604.2(as)-601.5(described)-603.1(earlier.)]TJ
0 -1.2203 TD
[(Moreover,)-274.8(we)-273.4(expected)-271.5(that)-275.7(in)-272.5(PBD)-271.3(dysfunctional)-273(connectiv-)]TJ
T*
[(ity)-274(in)-266.2(affective)-269.8(and)-265.1(regulatory)-270.7(regions)-275.3(may)-260.7(correlate)-272.3(with)-268.3(the)]TJ
0 -1.2266 TD
[(severity)-226(of)-218.2(manic)-224.6(and)-220.9(depressive)-220.3(symptoms)-221.8(and/or)-221(with)-224(per-)]TJ
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[(formance)-307.1(measures)-305.1(on)-297(the)-307.3(affective)-301.5(working)-305.4(memory)-300.1(task.)]TJ
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1.1128 -1.8336 TD
[(Our)-327.6(adolescent)-335.5(sample)-325.6(\(mean)-329.6(age)]TJ
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15.2445 0 TD
(=)Tj
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.7145 0 TD
(14.32)Tj
/F6 1 Tf
2.4153 0 TD
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[(2.76\))-324.4(consisted)]TJ
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[(of)-528(41)-530.1(un-medicated)-529.9(adolescents)-532.9(with)-527.5(PBD)-530.6(\(type)-525.1(I:)]TJ
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-25.4181 -1.2203 TD
[(Type)-457.6(II:)]TJ
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4.0467 0 TD
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[(7\))-455.2(and)-454.8(16)-454.3(HC.)-452(For)-456.8(this)-457.6(sample,)-455(the)-459(age)-452.8(range)]TJ
-5.482 -1.2203 TD
[(was)-312.3(from)-311.3(11)-308.8(to)-306.7(18)-308.8(years.)-312.3(We)-308.7(made)-309.8(every)-309.2(effort)-308.3(to)-313.1(match)-310(the)]TJ
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[(PBD)-328.2(and)-322(HC)-322.6(groups)-321.7(for)-320.1(IQ,)-324.2(as)-323.3(estimated)-321.8(with)-325.2(the)-319.9(Wechsler)]TJ
0 -1.2203 TD
[(Abbreviated)-264.6(Scale)-259.9(of)-256.2(Intelligence)-263.6(\(WASI\))-261.2(\(Psychological)-263.5(Cor-)]TJ
T*
[(poration,)-219.8(1999\),)-216.4(age,)-215.4(socioeconomic)-220.5(status)-219.4(\(SES\),)-218.8(gender,)-216.6(race,)]TJ
0 -1.2266 TD
[(and)-265.1(handedness)-258.4(as)-260.1(measured)-262.5(by)-255.4(a)-258.8(handedness)-264.7(questionnaire)]TJ
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[(\(Annett,)-309.6(1970\).)]TJ
1.1128 -1.2203 TD
[(Our)-314.9(participants)-324.2(were)-318.3(recruited)-318.7(from)-311.3(the)-319.9(child)-316.2(psychiatry)]TJ
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[(clinics)-532.3(at)-531.1(the)-528.6(University)-537.9(of)-528(Illinois)-529.6(at)-531.1(Chicago)-531.6(\(UIC\))-529.4(and)]TJ
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[(from)-222.8(community)-219(referrals.)-218.3(HC)-221.5(were)-217.1(recruited)-223.8(from)-216.5(the)-218.7(neigh-)]TJ
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[(boring)-221.6(community)-219(through)-218.8(an)-211.6(advertisement.)-222(This)-219.9(study)-212.9(was)]TJ
T*
[(approved)-439.3(by)-432.5(the)-433.7(UIC)-427.3(Institutional)-443.2(Review)-433.6(Board)-432.6(and)-429.5(was)]TJ
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44.7283 0 TD
[(PASSAROTTI)-304.6(ET)-300.7(AL.)]TJ
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[(each)-261.3(participant.)-256.3(We)-258.2(obtained)-257.3(an)-262.1(assent)-258.8(for)-256.9(children)-257(younger)]TJ
T*
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[(or)-325.9(older.)-329(Consent)-327.5(from)-324(at)-328.8(least)-327.2(one)-322.2(parent)-327.8(or)-325.9(legal)-327(guardian)]TJ
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1.1128 -2.447 TD
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[(PBD)-644.4(diagnosis)-648.8(was)-647.4(obtained)]TJ
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[(based)-324.3(on)-322.3(DSM-IV)-320.2(diagnosis)-320(of)-325.7(bipolar)-319.3(disorder)-324.7(with)-318.8(mixed,)]TJ
T*
[(manic,)-543.6(or)-540.9(hypomanic)-540(episode)-542.9(\(DSM-IV,)-544.9(2000\).)-538.9(Moreover,)]TJ
T*
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[(interviewed)-383.4(by)-369.2(a)-378.9(board-certied)-374.7(child)-379.5(psychiatrist)-379.7(\()-82.7(M.N.P.\))]TJ
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[(and)-397.9(two)-396.9(board-certied)-400(doctoral-level)-399.5(clinicians)-399.7(within)-395.3(our)]TJ
T*
[(research)-472.6(program,)-471.5(using)-469.3(the)-471.6(Washington)-470.1(University)-474.6(in)-468.5(St.)]TJ
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[(Louis)-429.3(Kiddie)-433.1(Schedule)-432.5(for)-427.6(Affective)-436.1(Disorders)-431.9(and)-423.2(Schizo-)]TJ
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[(phrenia)-663(\(WASH-U-KSADS\))-662.3(\(Geller)-658(et)-657.9(al.,)-653.8(1998\),)-659(supple-)]TJ
T*
[(mented)-408.9(by)-400.9(the)-402.1(episode)-410.1(characterization)-407.5(of)-401.6(bipolar)-407.8(disorder)]TJ
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[(from)-425.1(the)-427.4(KSADS)-426.2(-)-424.1(Present)-430.7(and)-423.2(Lifetime)-432(version)-423.3(\(Kaufman)]TJ
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[(et)-556.8(al.,)-552.6(2000\).)-551.5(In)-555.6(addition,)-553.3(the)-553.8(Young)-553.6(Mania)-554.8(Rating)-559.3(Scale)]TJ
T*
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[(Scale-Revised)-576.5(\(CDRS-R\))-572.7(\(Poznanski)-576.1(et)-569.4(al.,)-565.3(1984\))-567.6(assessed)]TJ
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[(manic)-496.5(and)-492.8(depressive)-498.5(symptom)-492.3(severity,)-494.4(respectively.)-498.5(All)]TJ
T*
[(available)-380.9(clinical)-376(information)-384.8(was)-375.5(reviewed)-382.3(to)-376.3(make)-380.8(a)-372.6(con-)]TJ
T*
[(sensus)-438.5(clinical)-439.2(diagnosis.)-436.7(Live)-437.1(diagnostic)-438.5(interviews)-438.7(of)-439.5(ten)]TJ
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[(cases)-266.9(were)-261.4(independently)-269.4(coded)-267.2(by)-261.8(two)-264.1(researchers)-265.8(to)-262.5(estab-)]TJ
0 -1.2203 TD
[(lish)-302.6(inter-rater)-306.9(diagnostic)-305.8(reliability)-299(\(Cohens)-310.5(kappa)]TJ
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22.9458 0 TD
(=)Tj
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(0.94\).)Tj
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-22.5538 -2.447 TD
[(Inclusion)-235.5(and)-240.9(exclusion)-231.5(criteria.)]TJ
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14.7071 0 TD
[(Inclusion)-235.7(criteria)-241.6(for)-237.9(par-)]TJ
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[(ticipants)-208.9(with)-198.7(PBD)-201.8(were)-204.5(as)-203.2(follows:)-202.3(1018)-199.9(years)-201.9(of)-199.3(age,)-202.8(a)-201.8(base-)]TJ
T*
[(line)-332.8(score)-326.4(greater)-334.4(than)-329.2(12)-321.5(on)-328.6(the)-332.5(YMRS)-328.2(\(Young)-332.8(et)-329.2(al.,)-325(1978\),)]TJ
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[(and)-252.5(consent)-250.8(to)-249.8(be)-250.9(scanned)-250.1(in)-247.2(a)-252.4(medication-free)-254.7(state.)-251.2(Patients)]TJ
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[(were)-229.7(either)-235.5(medication)-234.3(free)-228.6(\(not)-234.7(requiring)-230.6(a)-227.1(washout)-231.7(at)-227.6(study)]TJ
T*
[(entry\))-237(or)-237.4(sufciently)-242(unstable)-235.2(on)-233.8(previous)-239.3(medications)-235.6(to)-237.2(jus-)]TJ
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[(tify)-312.4(discontinuation)-322.6(of)-306.7(an)-312.7(ineffective)-315.1(treatment)-318.5(before)-311.7(begin-)]TJ
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[(ning)-425.7(a)-416.8(new)-422.2(treatment)-426(with)-420(the)-427.4(consent)-421.5(of)-420.6(parents)-423.9(and)-423.2(the)]TJ
T*
[(assent)-315.7(of)-306.7(patients.)-316.4(The)-309.8(washout)-313.9(period)-308.4(consisted)-318.5(of)-306.7(tapering)]TJ
T*
[(previous)-277.2(medications)-273.5(over)-269.7(1)-271.4(week)-271.4(before)-273.7(study)-276.1(entry,)-271(except)]TJ
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[(for)-383.3(those)-387.2(who)-387.2(received)-380(aripiprazole)-389(that)-383.2(required)-386.6(a)-378.9(4-week)]TJ
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[(washout)-528.9(period.)-526.3(All)-526.9(patients)-528.4(were)-526.9(medication)-525.1(free)-525.8(for)-528.7(at)]TJ
T*
[(least)-213.4(7)-208.2(days)-210.6(before)-216.8(scanning.)-210.8(None)-214.7(of)-211.9(the)-212.4(patients)-212.3(were)-210.8(on)-208.5(u-)]TJ
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[(oxetine)-366.2(that)-364.2(would)-360.1(have)-363.9(required)-361.3(a)-359.9(longer)-362.5(washout)-364.5(period.)]TJ
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[(Close)-254.3(clinical)-255.9(supervision)-260.2(and)-252.5(monitoring)-256.5(was)-255.4(provided)-249(dur-)]TJ
T*
[(ing)-213.7(drug)-211.8(free)-215.9(periods)-214.9(according)-211.9(to)-211.9(the)-212.4(approved)-218(IRB)-211.7(protocol.)]TJ
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[(Inclusion)-311.5(criteria)-311.1(for)-307.4(the)-307.3(HC)-310(participants)-311.6(included)-307.8(being)-306.5(10)]TJ
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[(18)-207.7(years)-208.2(of)-211.9(age)-206.2(and)-208.2(having)-204.7(a)-208.2(baseline)-211.5(YMRS)-208.1(score)]TJ
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(<)Tj
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[(12.)-204.3(Exclu-)]TJ
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[(sion)-396.7(criteria)-393.3(for)-389.6(all)-392.3(participants)-393.8(included:)-393(current)-397.8(substance)]TJ
T*
[(abuse/dependence,)-227.8(neurological)-227(complications,)-223.6(serious)-225.9(med-)]TJ
0 -1.2266 TD
[(ical)-378.9(illness,)-373.5(full-scale)-379.6(IQ)]TJ
/F6 1 Tf
11.1536 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(70,)-375(and)-372.6(contraindications)-383.9(to)-370(MRI)]TJ
-11.8744 -1.2203 TD
[(studies,)-317.3(including)-316.3(metallic)-310.8(implants,)-317.1(braces)-314.9(or)-313.3(retainers,)-315.8(and)]TJ
T*
[(claustrophobia.)-418.9(The)-411(HC)-411.1(participants)-412.8(were)-413.1(excluded)-410.5(if)-415(they)]TJ
0 -1.2266 TD
[(met)-257.2(criteria)-260.5(for)-263.2(a)-252.4(DSM-IV)-263.3(Axis)-255(I)-255(disorder)-261.5(or)-256.4(had)-258.8(a)-258.8(family)-255.6(his-)]TJ
0 -1.2203 TD
[(tory)-305.5(of)-300.4(affective)-301.4(illness.)]TJ
1.1128 -1.2203 TD
[(Behavioral)-370.7(and)-366.3(ICA)-370.4(data)-369.2(from)-368.2(the)-370.5(present)-373.8(samples)-371.2(of)-370(16)]TJ
-1.1128 -1.2266 TD
[(HC)-303.6(and)-303.1(41)-296.2(PBD)-302.9(patients)-307.1(have)-300.7(not)-297.5(been)-304.8(published)-306.3(earlier.)]TJ
/F9 1 Tf
0 -3.054 TD
[(The)-305.3(affective)-298.1(two-back)-299(working)-305.5(memory)]TJ
0 -1.2203 TD
[(task)-304.2(and)-297.8(fMRI)-302.4(session)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(Each)-239.1(participant)-240.7(underwent)-241.4(a)-233.5(7)-170.2(min)-238.4(fMRI)-233.2(scanning)-239.5(session)]TJ
-1.1128 -1.2203 TD
[(with)-350.5(a)-347.3(two-back)-348.1(working)-343.3(memory)-350.7(task.)-343.7(While)-350.8(the)-345.2(scanning)]TJ
0 -1.2266 TD
[(session)-215.9(included)-219.3(two)-213.5(tasks,)-212.3(one)-214.7(with)-211.4(blocks)-218.1(of)-211.9(angry)-214.8(and)-208.2(neu-)]TJ
0 -1.2203 TD
[(tral)-238.2(faces)-234.4(and)-233.5(another)-237.7(with)-230.3(blocks)-237(of)-237.2(happy)-231.3(and)-233.5(neutral)-236.5(faces,)]TJ
T*
[(for)-237.9(the)-237.7(purposes)-237.7(of)-237.2(this)-236.3(study)-238.2(we)-235.5(will)-233.5(focus)-239.1(only)-235.4(on)-240.1(the)-237.7(angry)]TJ
28.0042 74.5535 TD
[(and)-385.3(neutral)-394.6(face)-391.2(task)-385.1(blocks.)-391.7(Our)-390.8(face)-384.9(stimuli)-390.7(were)-394.1(80)-384.7(Gur)]TJ
0 -1.2203 TD
[(emotional)-304.3(faces)-304(\(Gur)-298.5(et)-303.9(al.,)-299.7(2002\))-302(with)-299.9(neutral)-306(and)-303.1(angry)-297(ex-)]TJ
T*
[(pressions)-546.7(that)-541.3(were)-545.9(balanced)-543.7(by)-540(gender,)-545.3(race,)-546.1(and)-543.3(facial)]TJ
0 -1.2267 TD
(expression.)Tj
1.1128 -1.2203 TD
[(This)-504.4(task)-511.5(consisted)-514.5(of)-509.1(four)-511.1(alternating)-512(30-sec)-512.1(blocks)-508.9(of)]TJ
-1.1128 -1.2203 TD
[(angry)-410.8(and)-410.6(neutral)-413.5(faces)-411.5(presented)-414.6(in)-405.3(a)-410.5(pseudo-random)-415.5(se-)]TJ
0 -1.2266 TD
[(quence.)-428.5(Each)-428.8(block)-425.4(consisted)-432.3(of)-426.9(ten)-427.4(trials.)-429.3(On)-430.1(each)-425.7(trial,)-428(a)]TJ
0 -1.2203 TD
[(face)-365.9(stimulus)-377.2(with)-369.4(a)-366.2(certain)-373.5(emotion)-370.8(\(i.e.,)-373.1(angry)-366.5(or)-370.2(neutral\))]TJ
T*
[(was)-388.1(presented)-395.6(for)-389.6(3)-170.2(sec)-392.5(and)-385.3(then)-392.8(disappeared,)-395.4(followed)-390.7(by)]TJ
T*
[(the)-376.8(next)-379(face)-378.5(for)-377(3)-170.2(sec.)-376.5(Participants)-381.2(responded)-382.1(by)-375.6(key)-375.5(press)]TJ
0 -1.2266 TD
[(if)-269.6(they)-273.7(saw)-268(the)-269.3(same)-270.2(emotional)-272.7(face)-271(\(i.e.,)-271.9(same)-270.2(face)-271(and)-271.5(emo-)]TJ
0 -1.2203 TD
[(tion\),)-367.6(as)-367.6(the)-364.2(one)-372.8(presented)-370.3(two)-365.3(trials)-369.5(earlier)-368.2(\(Fig.)-363.5(1\).)-369.6(In)-365.9(this)]TJ
T*
[(task,)-508.1(a)-505.3(two-back)-512.5(match)-506(trial)-513.6(always)-503.1(involved)-510.8(a)-511.7(match)-506.1(in)]TJ
0 -1.2267 TD
[(both)-535.9(face)-542.9(identity)-537.2(and)-543.3(face)-536.6(emotion.)-538.1(A)-538.8(2)0(0)-169.7(sec)-537.9(xation)-539.6(in)]TJ
0 -1.2203 TD
[(between)-306.8(blocks)-312.9(was)-306(included)-307.8(to)-306.7(allow)-308.2(for)-307.4(emotional)-310.6(arousal)]TJ
T*
[(to)-344.7(return)-347.9(to)-351(baseline.)-347.2(A)-342.8(color)-350.5(high-resolution)-351.1(LCD)-346(projector)]TJ
0 -1.2266 TD
[(projected)-486.5(visual)-484.2(stimuli)-485.5(onto)-489.9(a)-480.1(rear)-487.7(projection)-487(screen)-485(that)]TJ
0 -1.2203 TD
[(was)-438.7(viewed)-438.7(via)-433.7(an)-439.2(angled)-437.4(double-mirror)-438.7(system)-441.3(mounted)]TJ
T*
[(on)-227.5(a)-220.8(standard)-232.2(General)-227(Electric)-224.7(head)-227.1(coil.)-227(A)-229(camera)-224.1(monitored)]TJ
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[(ticipants)-303.7(were)-299.3(looking)-303(at)-303.5(the)-300.9(visual)-300.8(stimuli.)]TJ
/F9 1 Tf
0 -2.4406 TD
[(MRI)-298.8(protocols)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(Gradient-echo,)-289.9(echo-planar)-298.3(functional)-295.9(imaging,)-284.8(and)-290.4(struc-)]TJ
-1.1128 -1.2266 TD
[(tural)-441.9(acquisitions)-448.1(were)-444.7(performed)-442.6(with)-445.3(a)-442.1(3.0)-438.2(Tesla)-443.5(whole-)]TJ
0 -1.2203 TD
[(body)-748.1(scanner)-753.6(\(Signa;)-752.5(General)-751.8(Electric)-749.5(Medical)-747.3(System,)]TJ
T*
[(M)13.9(i)0(l)18.2(w)0(a)17.8(u)0(k)19.5(e)12.7(e,)-375.9(WI)17.8(\))-379.8(a)0(t)-373(t)0(h)15.1(e)-385.6(M)13.9(R)-383.6(Ce)18.9(nt)15.1(e)12.7(r)-386.4(wi)20.1(t)12.2(h)0(i)18.4(n)-382.8(th)15.1(e)-385.6(U)0(I)21.8(C)-385.9(H)12.7(o)0(s)14.9(p)0(i)20.4(t)12.2(al)15.9(.)]TJ
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[(he)22(ad)-521(wi)20.1(th)-522.3(f)12.2(o)0(a)16.7(m)-528.7(c)13.4(u)0(s)16.3(h)0(i)18.4(o)0(n)19.1(s)0(.)-522.7(T)0(2)22.8(*)0(-)17.8(w)0(e)17.4(i)15.4(gh)17.5(te)18.6(d)-527.8(f)0(u)17.1(n)0(c)16.3(t)12.2(io)19(na)16.1(l)-528.3(i)0(m)17.9(a)13.1(ge)21(s)]TJ
T*
[(we)17.4(re)-519.1(a)13.1(c)0(q)21.6(u)0(i)14.1(r)0(e)18.4(d)-527.8(wi)20.1(t)12.2(h)-528.2(a)-530.6(g)0(r)20.2(a)0(d)16.5(i)0(e)21.9(n)0(t)15.1(-)12.2(ec)19.8(ho)19.1(,)-527.7(e)0(c)13.5(h)0(o)19.1(-)12.2(pl)20.4(an)16.1(a)13.1(r)-531.8(se)17.8(qu)19.5(e)12.7(n)0(c)16.3(e)]TJ
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[(2)13.1(5)-157.6(ms)20.1(,)-527.7()0(i)18.8(p)-526.2(an)16.1(g)14.6(l)0(e)]TJ
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/F6 1 Tf
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[(,F)527.7(O)545.5(V).1(2)540.8(0)]TJ
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[(20)-170.7(c)-13.1(m)]TJ
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[(64)-536.5(m)15.1(a)0(t)19(r)0(i)14.7(x)0(,)-529.9(3)0(.)16.5(1)13.1(25)]TJ
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T*
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T*
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T*
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T*
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T*
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[(sponded)-381.5(to)-376.3(the)-376.8(same)-377.7(time)-380.8(point.)-381.2(The)-373(rst)-378.5(functional)-384.4(image)]TJ
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[(volume)-227.2(of)-224.5(each)-229.7(participant)-228.1(was)-230.1(used)-226.9(to)-224.5(determine)-229.7(the)-225.1(param-)]TJ
0 -1.2203 TD
[(eters)-482.8(for)-484.5(spatial)-483.4(normalization)-488.1(into)-484.4(Montreal)-483.3(Neurological)]TJ
T*
[(Institute)-714.9(\()-82.7(MNI\))-709.5(standardized)-712.4(space)-709.5(employed)-708(in)-708.8(SPM5)]TJ
0 -1.2266 TD
[(using)-368.1(nonlinear)-374.2(transformation.)-373.6(The)-366.7(normalization)-374.3(parame-)]TJ
0 -1.2203 TD
[(ters)-375.4(determined)-384.4(for)-377(the)-376.8(rst)-378.5(functional)-378.1(volume)-378.9(were)-375.2(subse-)]TJ
T*
[(quently)-390.5(applied)-391.6(to)-395.3(all)-386(of)-395.3(the)-389.5(168)-390.6(functional)-390.8(image)-390.6(volumes)]TJ
T*
[(for)-301.1(each)-305.6(participant.)]TJ
/F9 1 Tf
0 -2.3901 TD
[(ICA)-301.4(estimation)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(All)-324.6(participants)-332.5(fMRI)-328.1(time)-330.3(series)-329.1(for)-326.4(the)-332.5(affective)-326.7(N-back)]TJ
-1.1128 -1.2266 TD
[(task)-562.1(were)-558.5(analyzed)-556.5(using)-564.1(a)-555.9(group)-560.7(ICA)-560.1(algorithm)-559.7(\(GIFT)]TJ
0 -1.2203 TD
[(v1.3h;)-571.7(http:/)222.3(/icatb.sourceforge.net\))-584(\(Calhoun)-571(et)-575.8(al.,)-565.3(2001\).)]TJ
T*
[(The)-354(fMRI)-353.4(time)-355.5(series)-354.4(data)-350.3(for)-358(all)-354.3(participants)-355.9(were)-349.9(concate-)]TJ
T*
[(nated)-297.1(and)-296.8(then)-291.7(subjected)-299.1(to)-294.1(two)-295.7(principal)-300.7(component)-295.4(analy-)]TJ
0 -1.2266 TD
[(sis)-493(data)-495.7(reduction)-494.9(stages)-493.8(\(Calhoun)-495.1(et)-493.6(al.,)-495.7(2001\).)-494.6(The)-493.2(data)]TJ
0 -1.2203 TD
[(underwent)-266.6(a)-258.7(nal)-262.4(ICA)-262.9(rotation)-266.5(using)-260.6(Infomax)-267.2(that)-263.1(produced)]TJ
T*
[(46)-308.8(maximally)-302.2(independent)-312.1(components)-315.7(\(Bell)-307.6(and)-309.4(Sejnowski,)]TJ
0 -1.2266 TD
[(1995\).)-418.7(The)-417.3(minimum)-415.5(description)-417.6(length)-419.8(criterion)-425.3(was)-413.4(used)]TJ
0 -1.2203 TD
[(to)-502.8(determine)-501.5(the)-496.9(number)-500.5(of)-502.7(components)-499.1(\(Li)-500.2(et)-499.9(al.,)-495.7(2007\).)]TJ
T*
[(Using)-311.2(the)-307.3(ICA-derived)-312.1(group)-307.8(solution,)-312.9(data)-306(for)-307.4(each)-305.6(partici-)]TJ
0 -1.2266 TD
[(pant)-403.1(were)-406.8(then)-405.5(back-reconstructed)-406.3(\(Erhardt)-403.3(et)-405(al.,)-400.9(2010\))-403.2(so)]TJ
0 -1.2203 TD
[(that)-440.1(individual)-436.1(participant)-436.7(variability)-441.2(was)-432.4(retained)-440.4(for)-440.2(hy-)]TJ
T*
[(pothesis)-406.1(testing.)-402.1(For)-399.9(each)-400.4(component,)-399.5(this)-400.7(back-reconstruc-)]TJ
0 -1.2266 TD
[(tion)-604.5(method)-601.4(produced)-599.4(a)-600.2(spatial)-597.3(map)-599.1(representing)-607(brain)]TJ
0 -1.2203 TD
[(regions)-231(within)-230.9(each)-229.7(component)-232.2()55(network,)55.9()-229.5(and)-227.2(a)-227.1(time)-229.1(course)]TJ
T*
[(of)-300.4(BOLD)-301.3(signal)-300.2(change)-307.1(across)-302.1(the)-300.9(fMRI)-302.8(paradigm.)]TJ
/F9 1 Tf
0 -2.5039 TD
[(Selection)-303.4(of)-298.8(components)-302.6(for)-300.9(analysis)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(ICASSO)-225(analyses)-221.5(\(Li)-222(et)-221.7(al.,)-223.9(2007\))-219.8(in)-221.9(GIFT)-223.3(were)-223.4(run)-226.7(30)-220.3(times)]TJ
-1.1128 -1.2203 TD
[(using)-399.7(FastICA)-395.1(in)-398.9(order)-392.8(to)-395.3(investigate)-402.9(signal)-395.1(coherence)-400.5(and)]TJ
T*
[(replicability)-242.7(for)-237.9(each)-236(of)-237.2(the)-237.7(estimated)-239.6(46)-239.3(independent)-242.5(compo-)]TJ
T*
[(nents,)-403.4(and)-404.2(to)-401.6(identify)-404.4(those)-406.2(with)-401(acceptable)-405.5(reliability)-406.5(\(i.e.,)]TJ
/F6 1 Tf
0 -1.2266 TD
(>)Tj
/F4 1 Tf
.7208 0 TD
[(80%\))-355.2(that)-351.6(could)-357.7(be)-352.1(retained)-358.2(for)-358(further)-354.7(analysis.)-354.6(Next,)-359.5(the)]TJ
-.7208 -1.2203 TD
[(correlation)-497.1(of)-490.1(each)-495.3(components)-501(spatial)-489.8(map)-491.6(with)]TJ
/F5 1 Tf
23.4896 0 TD
[(a)-492.5(priori)]TJ
/F4 1 Tf
-23.4896 -1.2203 TD
[(probabilistic)-268.6(maps)-265.3(of)-268.8(gray)-262(matter,)-267.1(white)-268.2(matter,)-267.1(and)-265.1(cerebral)]TJ
0 -1.2266 TD
[(spinal)-335.1(uid)-333.4(\(CSF\))-339.1(within)-338.4(MNI)-336(space)-336.5(\(templates)-339.6(provided)-331.2(in)]TJ
0 -1.2203 TD
[(SPM5\))-295.8(was)-293.3(calculated)-293.9(for)-294.8(all)-291.1(components)-296.7(in)-297.8(order)-291.6(to)-294.1(discard)]TJ
T*
[(those)-273.4(that)-269.4(could)-269.2(be)-263.6(an)-268.5(artifact,)-272.4(because)-271.2(they)-267.4(had)-271.5(greater)-264.8(than)]TJ
0 -1.2266 TD
[(a)-271.4(0.25)-267(correlation)-275.8(to)-268.8(CSF)-268.6(or)-275.4(white)-268.2(matter,)-273.4(or)-269(which)-270.5(showed)-277.6(a)]TJ
0 -1.2203 TD
[(low)-311.4(correlation)-320.1(with)-318.8(gray)-312.5(matter.)-311.4(This)-314.7(step)-319.2(primarily)-312(identi-)]TJ
T*
[(ed)-271.5(and)-265.1(excluded)-271.4(obvious)-269.8(signal)-268.6(artifacts)-270.8(\(e.g.,)-272.8(head)-265(motion,)]TJ
T*
[(cardiac)-529.6(inow)-532.8(pulsatile)-533(motion\).)-538.7(Of)-528.3(the)-534.9(components)-537(that)]TJ
0 -1.2266 TD
[(were)-217.1(retained)-225.4(through)-218.8(this)-217.4(process,)-218.2(we)-222.8(proceeded)-218.5(by)-217.5(discard-)]TJ
0 -1.2203 TD
[(ing)-422.3(components)-423.2(in)-424.2(which)-422.2(there)-428(was)-419.8(no)-423.5(evidence)-420.6(that)-421.2(they)]TJ
T*
[(were)-501.6(engaged)-507.7(by)-502(any)-500.5(aspect)-501.3(of)-502.8(the)-503.3(fMRI)-505.1(task.)-501.8(To)-505.3(assess)]TJ
0 -1.2266 TD
[(task)-574.8(engagement,)-584.8(multiple)-574(regression)-580.7(analyses)-582(were)-577.5(per-)]TJ
0 -1.2203 TD
[(formed)-251(between)-256.2(component)-257.5(time)-254.4(courses)-253.2(and)-252.5(an)-249.5(overall)-251(con-)]TJ
T*
[(dition)-320.2(model)-316.6(of)-313.1(the)-319.9(affective)-320.4(N-back)-317.9(task)-315.5(\(i.e.,)-316.2(one)-315.9(condition)]TJ
0 -1.2266 TD
[(model)-278.7(for)-275.8(both)-276.6(angry)-278(and)-271.5(neutral)-280.7(blocks\))-275.4(to)-275.1(provide)-277.6(associa-)]TJ
0 -1.2203 TD
[(tion)-383.2(coefcients)-392.7(\()]TJ
/F10 1 Tf
7.6823 0 TD
(b)Tj
/F4 1 Tf
.5501 0 TD
[(-weights\).)-391.6(One)-385.7(sample)]TJ
/F5 1 Tf
10.4518 0 TD
(t)Tj
/F4 1 Tf
.3225 0 TD
[(-test)-388.3(against)-385.2(zero)]TJ
-19.0067 -1.2203 TD
[(was)-198.5(carried)-202.6(out)-206.9(on)-202.2(the)]TJ
/F10 1 Tf
9.7499 0 TD
(b)Tj
/F4 1 Tf
.7524 0 TD
[(weights)-204.3(\(pooled)-203.5(across)-200.9(groups\))-208.4(to)-199.2(de-)]TJ
-10.5024 -1.2266 TD
[(termine)-618.8(whether)-616.4(the)-617.1(evidence)-616.6(for)-617.3(task)-612.7(engagement)-619.9(was)]TJ
0 -1.2203 TD
[(greater)-340.7(than)-335.5(zero.)-340.9(By)-336.2(doing)-333.3(so,)-342.1(26)-334.1(components)-341(were)-337.2(signi-)]TJ
T*
[(cantly)-320.4(\()]TJ
/F5 1 Tf
3.4776 0 TD
(p)Tj
/F6 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.05\))-318.1(associated)-326.8(with)-318.8(the)-326.2(overall-condition)-324.2(model)]TJ
-4.8623 -1.2203 TD
[(and)-309.4(were,)-314.9(therefore,)-314.6(retained.)-310.5(Finally,)-309.8(to)-313.1(select)-314.2(a)-309.3(nal)-306.6(subset)]TJ
0 -1.2266 TD
[(of)-205.6(components)-214.5(on)-202.2(which)-213.6(to)-205.6(test)-204.5(our)-207.2(hypotheses,)-217.1(we)-203.9(compared)]TJ
/F10 1 Tf
0 -1.2203 TD
(b)Tj
/F4 1 Tf
.5501 0 TD
[(-weights)-464(representing)-461.6(the)-459(degree)-456.7(of)-458.5(task)-454.6(engagement)-461.8(be-)]TJ
-.5501 -1.2203 TD
[(tween)-302.5(HC)-303.6(and)-296.8(PBD)-302.9(groups.)-305.7(Twenty-six)-304.8(ANOVAs)-300.8(were)-299.3(per-)]TJ
27.9978 74.5535 TD
[(formed,)-671.2(one)-670(for)-667.8(each)-672.3(of)-667.2(the)-667.7(retained)-674.3(components.)-672.7(The)]TJ
0 -1.2203 TD
[(mixed-factor)-382.9(ANOVA)-381.7(model)-379.8(included)-377.4(group)-383.7(\(PBD,)-375.9(HC\))-380(as)]TJ
T*
[(the)-218.7(between-subjects)-225.4(factor,)-214.8(and)-220.9(face)-214.1(emotion)-219.1(\(angry,)-218.2(neutral\))]TJ
0 -1.2267 TD
[(as)-241.1(the)-237.7(within-subject)-243.1(factor.)-240.1(Components)-240.7(for)-237.9(which)-238.8(there)-238.3(was)]TJ
0 -1.2203 TD
[(evidence)-996(for)-990.3(signicant)-989.3(\()]TJ
/F5 1 Tf
13.1137 0 TD
(p)Tj
/F6 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.05\))-988.3(group,)-987.3(valence)-992.6(or)]TJ
-14.4984 -1.2203 TD
(group)Tj
/F6 1 Tf
2.839 0 TD
()Tj
/F4 1 Tf
.7145 0 TD
[(valence)-297.1(interactions)-296.5(were)-293(retained)-294.9(for)-288.5(study)-295.1(hypoth-)]TJ
-3.5535 -1.2266 TD
[(esis)-214.7(testing)-215.8(so)-206.4(that)-212.5(we)-216.5(could)-206(test)-217.1(differences)-214.2(between)-211.9(PBD)-214.4(and)]TJ
0 -1.2203 TD
[(HC)-436.4(in)-436.9(regional)-435.1(functional)-435(connectivity)-438.5(with)-432.7(regard)-438.2(to)-433.2(net-)]TJ
T*
[(works)-390.2(involved)-390.7(in)-386.3(the)-389.5(integration)-388.8(of)-388.9(working)-387.6(memory)-388.6(and)]TJ
T*
[(face)-302.7(emotion)-307.6(processing.)]TJ
/F9 1 Tf
0 -2.3901 TD
[(Visualization)-307.7(of)-298.8(whole-brain,)-302.9(task-engaged)-299.3(components)]TJ
/F4 1 Tf
1.1128 -1.8336 TD
[(For)-286.1(each)-280.3(component)-282.8(that)-288.4(exhibited)-279.5(signicant)-287.4(effects)-286.3(from)]TJ
-1.1128 -1.2266 TD
[(the)-585.5(ANOVA,)-586.9(component)-580(spatial)-584.6(structure)-587.3(was)-577.8(identied)]TJ
0 -1.2203 TD
[(using)-677.9(an)-673.1(SPM5)-674.7(voxel-wise,)-676.4(one-sample)]TJ
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19.386 0 TD
(t)Tj
/F4 1 Tf
.3225 0 TD
[(-test)-679.2(across)-675.1(all)]TJ
-19.7085 -1.2203 TD
[(study)-206.6(participants)-204.1(\()]TJ
/F5 1 Tf
8.5928 0 TD
(p)Tj
/F6 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.01)-203.8(family-wise)-205.6(error)-200.8(rate\))-203.4(and)-201.9(visual-)]TJ
-9.9776 -1.2203 TD
[(ized)-296.8(by)-287(overlaying)-294.8(these)-295.8(results)-293.1(on)-297(axial)-286.5(slices)-293.4(of)-294.1(representa-)]TJ
0 -1.2266 TD
[(tive)-308.1(brain)-296.1(anatomy.)]TJ
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0 -2.4976 TD
[(Study)-300.6(hypothesis)-305.7(testing)]TJ
/F2 1 Tf
1.1128 -1.8336 TD
[(Primary)-441(analyses.)]TJ
/F4 1 Tf
9.0797 0 TD
[(To)-435.7(test)-438.4(our)-434.8(hypotheses)-441.9(about)-438.5(group)]TJ
-10.1925 -1.2203 TD
[(differences)-416.5(in)-405.3(functional)-409.7(connectivity,)-409.8(two-sample)]TJ
/F5 1 Tf
22.8194 0 TD
(t)Tj
/F4 1 Tf
.3225 0 TD
[(-tests)-408.6(in)]TJ
-23.1419 -1.2266 TD
[(SPM5)-225.8(were)-223.4(performed)-221.3(on)-221.1(the)-225.1(spatial)-224.2(maps)-221(depicting)-227.5(network)]TJ
0 -1.2203 TD
[(structure)-606.2(in)-595(each)-596.4(participant.)-604.1(These)-595.5(analyses)-600.9(determined)]TJ
T*
[(whether)-287.6(the)-275.6(PBD)-277.6(group)-282.5(had)-277.8(any)-279.2(regional)-277(decits)-282.4(or)-275.4(excesses)]TJ
0 -1.2266 TD
[(of)-313.1(functional)-314.9(connectivity)-318.4(relative)-311.8(to)-306.7(the)-313.6(HC)-310(group.)-310.7(In)-315.3(order)]TJ
0 -1.2203 TD
[(to)-351(correct)-357.2(for)-345.4(multiple)-352.7(voxel-wise)-357.4(comparisons,)-351.5(we)-349.3(adopted)]TJ
T*
[(AlphaSim)-539.9(cluster)-537.7(thresholding)-542(\(Ward,)-530.4(2000\),)-532.6(restricted)-540.4(to)]TJ
0 -1.2266 TD
[(in-brain)-233.9(voxels,)-228.3(which)-232.5(used)-226.9(a)-227.1(contiguity)-232.3(threshold)-227.1(\(minimum)]TJ
0 -1.2203 TD
[(cluster)-284.8(size)]TJ
/F6 1 Tf
5.0204 0 TD
(=)Tj
/F4 1 Tf
.7208 0 TD
[(11;)-273.8(uncorrected)]TJ
/F5 1 Tf
7.0247 0 TD
(p)Tj
/F6 1 Tf
.6639 0 TD
(=)Tj
/F4 1 Tf
.7208 0 TD
[(0.01\))-280.1(that)-282(ensured)-281.4(an)-281.1(experi-)]TJ
-14.1507 -1.2203 TD
[(ment-wise,)-226.1(Type)-217.3(1)-214.5(error)-219.7(rate)-221.9(of)]TJ
/F5 1 Tf
13.5437 0 TD
(p)Tj
/F6 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.02)-216.4(\(corrected)]TJ
/F5 1 Tf
6.5569 0 TD
(p)Tj
/F4 1 Tf
.4995 0 TD
[(\).)-218.4(Next,)-220.4(we)]TJ
-21.9848 -1.2266 TD
[(identied)-241(clusters)-235.5(of)-230.9(voxels)-231.7(with)-236.6(a)-233.5(minimum)-232.1(size)-231.9(of)-230.9(11)-233(voxels)]TJ
8.9663 0 0 8.9663 313.0582 364.4787 Tm
[(that)-516(exhibited)-507.2(signicant)-515(group)-510.1(differences)-511.4(at)-512.1(a)-505.3(corrected)]TJ
/F5 1 Tf
0 -1.2203 TD
(p)Tj
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(<)Tj
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.7208 0 TD
[(0.02)-298.6(in)-297.8(the)]TJ
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4.8623 0 TD
(t)Tj
/F4 1 Tf
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[(-test)-299.8(maps.)]TJ
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-5.4693 -2.447 TD
[(Secondary)-337.3(analyses.)]TJ
/F4 1 Tf
10.3063 0 TD
[(We)-334(also)-335.9(conducted)-341.2(a)-334.6(series)-341.8(of)-338.4(sec-)]TJ
-11.4192 -1.2203 TD
[(ondary)-488(analyses)-480.8(to)-483.8(better)-486.4(characterize)-486.2(\(i\))-485(the)-484.3(relevance)-487.4(of)]TJ
T*
[(within-group)-703.6(regional)-700.6(connectivity)-697.7(differences)-701(based)-697.3(on)]TJ
0 -1.2266 TD
[(task)-246(conditions)-251.1(\(i.e.,)-246.6(angry)-240.1(and)-246.2(neutral)-249.1(faces\),)-244.1(and)-246.2(\(ii\))-248.3(correla-)]TJ
0 -1.2203 TD
[(tions)-460.4(between)-458.5(voxel-wise)-458.6(regional)-454(connectivity)-457.5(values)-461.6(and)]TJ
T*
[(clinical)-350.7(or)-344.9(behavioral)-353.1(measures.)-345.9(First,)-348.5(a)-347.3(supplemental)-348.3(SPM5)]TJ
0 -1.2266 TD
[(correlation)-775.3(analysis)-775.3(examined)-774(the)-768.8(linear)-769.3(association)-776.1(of)]TJ
0 -1.2203 TD
[(individual)-600.5(component)-605.3(spatial)-597.3(maps)-594.1(to)-597.6(each)-602.8(participants)]TJ
/F10 1 Tf
T*
(b)Tj
/F4 1 Tf
.5564 0 TD
[(-weights)-502(\(representing)-506.3(the)-503.3(degree)-501(of)-496.4(component)-504.1(engage-)]TJ
-.5564 -1.2203 TD
[(ment\))-634.1(for)-629.9(angry)-625.8(or)-629.4(neutral)-628.5(faces.)-629.4(This)-624.6(analysis)-629.8(showed)]TJ
0 -1.2266 TD
[(which)-422.2(brain)-416.2(regions)-420.7(of)-414.2(any)-418.3(given)-416.6(component)-421.9(were)-419.4(speci-)]TJ
0 -1.2203 TD
[(cally)-263.2(implicated)-258.3(in)-259.8(the)-256.7()55(t)56()-261.1(o)0(f)-256.2(its)-258.2(time)-260.7(course)-258.2(to)-256.2(the)-263(canonical)]TJ
T*
[(hemodynamic)-286.2(response)-288.8(model)-285(for)-282.2(angry)-284.3(or)-281.7(neutral)-287.1(blocks)-281.3(in)]TJ
0 -1.2266 TD
[(each)-457.3(group)-453.2(separately.)-456.1(In)-454.4(this)-457.6(way,)-451.1(it)-452.9(was)-451.4(possible)-454.4(to)-458.5(see)]TJ
0 -1.2203 TD
[(whether)-382.4(or)-376.5(not)-379.7(a)-372.6(particular)-383(regions)-378.3(functional)-378.1(connectivity)]TJ
T*
[(was)-400.8(more)-405.6(or)-401.8(less)-398.1(important)-401.8(to)-401.6(processing)-403.7(angry)-404.5(or)-401.8(neutral)]TJ
0 -1.2266 TD
[(valence)-398.3(in)-386.3(faces)-392.5(\(i.e.,)-392(more)-393(strongly)-387.7(implicated)-391.1(in)-392.6(PBD)-391.4(net-)]TJ
0 -1.2203 TD
[(work)-306.7(connectivity)-305.7(abnormality\).)]TJ
1.1128 -1.2203 TD
[(Next,)-460.7(SPM5)-459.7(correlation)-465.5(analyses)-455.5(examined)-464.2(relationships)]TJ
-1.1128 -1.2266 TD
[(between)-521.8(clinical)-515.1(measures)-513.7(\(i.e.,)-512.2(YMRS,)-514.5(CDRS)-516.4(scores\))-517.9(and)]TJ
0 -1.2203 TD
[(spatial)-546.7(maps)-537.2(for)-541.4(individual)-537.3(PBD)-543.2(participants)-539.2(for)-541.4(each)-539.5(of)]TJ
T*
[(the)-737.2(considered)-743.9(networks.)-738.3(Finally,)-733.4(we)-735(performed)-739.8(SPM5)]TJ
T*
[(correlation)-433.9(analyses)-430.2(between)-433.2(network)-430.6(maps)-429.7(in)-424.2(each)-432(group)]TJ
0 -1.2266 TD
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-1.8779 -1.2203 TD
[(involved)-264.2(in)-259.8(perceptual)-266.6(processing)-264.6(of)-262.5(facial)-258.8(features)-262.9(and)-258.8(emo-)]TJ
0 -1.2266 TD
[(tion)-269.4(\(Haxby)-263.9(et)-265.9(al.,)-261.8(2002;)-266.5(Passarotti)-263.9(et)-265.9(al.,)-261.8(2007;)-266.5(Pavuluri)-265(et)-265.9(al.,)]TJ
0 -1.2203 TD
[(2008\),)-235.4(including)-234.1(occipital)-240.9(regions,)-233.9(fusiform)-235.8(gyrus,)-236.4(parahippo-)]TJ
T*
[(campal)-222.1(gyrus,)-217.5(amygdala,)-216.7(middle)-219.2(temporal)-220.8(and)-220.9(parietal)-217.2(gyrus)]TJ
T*
[(as)-335.9(well)-337.4(as)-335.9(DLPFC.)-342.1(Therefore,)-336.1(it)-339.1(was)-337.6(labeled)-336.3(the)-338.9()55(Face)-340.1(Emo-)]TJ
0 -1.2266 TD
[(tion)-427.5(Processing)-429(Network)51.5()-419.2(\(Supplementary)-429.7(Fig.)-426.3(S1;)-424.5(Supple-)]TJ
0 -1.2203 TD
[(mentary)-353.7(Data)-355(are)-354.2(available)-355.6(online)-357.9(at)-354.1(www.liebertpub.com/)]TJ
T*
(brain\).)Tj
/F2 1 Tf
1.1128 -2.447 TD
[(Affective)-493.9(Working)-487.5(Memory)-494.3(Network.)]TJ
/F4 1 Tf
17.5018 0 TD
[(We)-492.1(identied)-493.9(an-)]TJ
-18.6147 -1.2203 TD
[(other)-386.6(component)-390.3(that)-389.5(revealed)-386.6(a)-385.2(signicant)-388.6(effect)-386.2(of)-388.9(group)]TJ
0 -1.2266 TD
([F\(1,55\))Tj
/F6 1 Tf
3.4397 0 TD
(=)Tj
/F4 1 Tf
.7145 0 TD
(4.33,)Tj
/F5 1 Tf
2.4975 0 TD
(p)Tj
/F6 1 Tf
.6702 0 TD
(=)Tj
/F4 1 Tf
.7145 0 TD
[(0.04])-501.4(\(Table)-497.7(3\),)-496.1(indicating)-504.6(that)-497(PBD)-498.9(and)]TJ
-8.0364 -1.2203 TD
[(control)-367(participants)-362.2(engaged)-362.3(this)-362.8(network)-361(to)-363.6(a)-359.9(different)-365.9(de-)]TJ
T*
[(gree)-441.2(during)-446.4(the)-440(fMRI)-441.9(task.)-444.9(This)-441.2(network)-443.2(included)-447(regions)]TJ
T*
[(that)-598.2(are)-600.8(a)-593.9(part)-602.7(of)-597.6(the)-598.1(working)-602.6(memory)-597.3(circuit)-602.5(such)-599.7(as)]TJ
27.9978 54.9904 TD
[(DLPFC,)-588.6(VLPFC,)-583.7(orbitofrontal)-588.3(cortex)-580.7(\(OFC\),)-586.9(medial)-582.4(PFC,)]TJ
0 -1.2203 TD
[(insula,)-376(caudate,)-366.4(dorsal)-371.2(and)-372.6(perigenual)-371.7(ACC,)-371.4(mid-cingulate,)]TJ
T*
[(as)-405.5(well)-394.3(as)-405.5(temporal)-397.8(and)-397.9(parietal)-406.9(regions)-401.7(\(DEsposito,)-402.6(2007;)]TJ
0 -1.2267 TD
[(Owen)-286.2(et)-278.6(al.,)-274.4(2005\).)-279.6(This)-283.1(network)-278.8(also)-279(included)-282.6(the)-282(amygdala)]TJ
0 -1.2203 TD
[(and)-315.7(superior)-315.1(temporal)-322(sulcus)-311.7(\(STS\),)-320(due)-314.1(to)-313.1(the)-313.6(affective)-320.4(and)]TJ
T*
[(face)-378.5(processing)-378.4(components)-378.9(of)-376.3(the)-370.5(task)-378.8(\(Braver)-371.7(et)-373.4(al.,)-375.6(2001;)]TJ
0 -1.2266 TD
[(Passarotti)-428.3(et)-424(al.,)-419.9(2010c,)-423.9(2011\).)-418.7(We)-422.6(labeled)-424.8(this)-426(network)-424.3(the)]TJ
0 -1.2203 TD
[()48.7(Affective)-330.5(Working)-321.8(Memory)-326.6(Network)51.5()-324.3(\(Fig.)-325.6(2\).)-325.4(The)-328.8(regions)]TJ
T*
[(that)-389.5(exhibited)-387(group)-390(differences)-391.2(had)-385.3(increased)-383.6(engagement)]TJ
T*
[(to)-351(the)-351.5(network)-354.7(during)-345.2(the)-351.5(task)-353.5(in)-348.4(the)-351.5(overall)-345.8(network)-354.7(map,)]TJ
0 -1.2266 TD
[(unless)-390.2(otherwise)-386.7(indicated.)-385.3(As)-382.1(illustrated)-384.1(in)-386.3(Table)-383.4(4,)]TJ
/F5 1 Tf
24.0776 0 TD
(t)Tj
/F4 1 Tf
.3225 0 TD
(-tests)Tj
-24.4001 -1.2203 TD
[(in)-342(SPM5)-339.6(\(with)-338.3(AlphaSim)-343.9(corrected)]TJ
/F5 1 Tf
15.8768 0 TD
(p)Tj
/F6 1 Tf
.6639 0 TD
(<)Tj
/F4 1 Tf
.7208 0 TD
[(0.02\))-337(found)-339.8(that)-345.3(PBD)]TJ
-17.2615 -1.2203 TD
[(showed)-460.9(greater)-460.8(connectivity)-463.8(relative)-457.2(to)-458.5(HC)-455.4(in)-455.8(left)-459.6(DLPFC)]TJ
0 -1.2267 TD
[(and)-429.5(caudate,)-435.9(and)-429.5(right)-429.8(VLPFC)-429.1(and)-429.5(medial)-430.7(PFC)-429.6(\(note)-430.6(that)]TJ
0 -1.2203 TD
[(the)-307.3(right)-303.4(medial)-304.2(PFC)-296.8(exhibited)-311.1(reduced)-298(BOLD)-307.6(signal)-300.2(activa-)]TJ
T*
[(tion)-357.9(during)-357.8(the)-357.8(task)-353.5(in)-354.7(the)-357.8(overall)-358.5(network,)-357.6(as)-354.9(indicated)-357.1(by)]TJ
0 -1.2266 TD
[(downward)-369.7(arrows)-367(in)-367.3(Table)-370.8(4\).)-369.6(PBD)-366.2(exhibited)-368.1(reduced)-367.5(con-)]TJ
0 -1.2203 TD
[(nectivity)-521.6(relative)-514.1(to)-515.4(HC)-512.3(in)-519.1(the)-509.6(junction)-518.7(of)-515.4(right)-518.3(DLPFC/)]TJ
T*
[(VLPFC,)-204.4(amygdala,)-204.1(bilateral)-198.5(STS)-202.3(and)-201.9(left)-206.7(mid)-200.1(OFC,)-200.2(and)-201.9(precu-)]TJ
0 -1.2266 TD
[(neus,)-344(as)-335.9(well)-343.7(as)-335.9(in)-342(right)-341.3(perigenual)-340.1(ACC)-343.2(and)-334.7(mid-cingulate)]TJ
0 -1.2203 TD
[(gyrus)-347.3(\(Note)-338.7(that)-345.3(the)-345.2(right)-341.3(perigenual)-346.4(ACC,)-339.8(right)-341.3(midcingu-)]TJ
T*
[(late)-325.9(gyrus,)-318.6(and)-322(the)-319.9(left)-326.8(OFC)-317.5(exhibited)-323.8(reduced)-323.3(BOLD)-320.3(signal)]TJ
T*
[(activation)-304.1(during)-300.9(the)-300.9(task)-296.6(in)-297.8(the)-300.9(overall)-301.5(network)-297.8(map,)-298.5(as)-298(in-)]TJ
0 -1.2266 TD
[(dicated)-305.9(by)-299.7(downward)-300.2(arrows)-303.8(in)-297.8(Table)-301.2(4\).)]TJ
/F2 1 Tf
1.1128 -2.4406 TD
[(Affect)-240.1(Evaluation)-232(and)-234.6(Regulation)-241.8(Network.)]TJ
/F4 1 Tf
19.4872 0 TD
[(An)-238.7(additional)]TJ
-20.6 -1.2266 TD
[(component)-1237.5(showed)-1238.6(a)-1226.2(signicant)-1235.8(effect)-1239.8(of)-1229.9(group)]TJ
0 -1.2203 TD
([F\(1,55\))Tj
/F6 1 Tf
3.4397 0 TD
(=)Tj
/F4 1 Tf
.7208 0 TD
(4.01,)Tj
/F5 1 Tf
2.5039 0 TD
(p)Tj
/F6 1 Tf
.6639 0 TD
(=)Tj
/F4 1 Tf
.7208 0 TD
[(0.05])-501.4(and)-505.4(of)-509.1(face)-505(emotion)-503.6([F\(1,55\))]TJ
/F6 1 Tf
15.9021 0 TD
(=)Tj
/F4 1 Tf
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(5.45,)Tj
/F5 1 Tf
-24.672 -1.2203 TD
(p)Tj
/F6 1 Tf
.6702 0 TD
(=)Tj
/F4 1 Tf
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[(0.02],)-365.2(and)-372.6(a)-372.6(nonsignicant)-372.8(trend)-374.2(for)-370.7(a)-372.6(group)]TJ
/F6 1 Tf
20.2523 0 TD
()Tj
/F4 1 Tf
.7208 0 TD
[(face)-372.2(emo-)]TJ
-22.3641 -1.2266 TD
[(tion)-332.6(interaction)-339.4([F\(1,55\))]TJ
/F6 1 Tf
10.5024 0 TD
(=)Tj
/F4 1 Tf
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(2.98,)Tj
/F5 1 Tf
2.3268 0 TD
(p)Tj
/F6 1 Tf
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(=)Tj
/F4 1 Tf
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[(0.09])-330.7(\(Table)-333.3(3\).)-331.7(The)-328.8(spatial)]TJ
-14.9347 -1.2203 TD
[(network)-304.1(included)-301.5(a)-296.7(fronto-cingulate-temporo-parietal-limbic)]TJ
T*
[(circuit,)-472.6(with)-464.3(regions)-465(that)-465.4(have)-465.1(been)-469.2(often)-468.6(found)-466.2(to)-464.8(be)-465.9(in-)]TJ
0 -1.2266 TD
[(volved)-213(in)-202.9(evaluation)-210.7(of)-205.6(face)-207.8(emotion)-206.4(valence)-208.6(and)-201.9(in)-209.2(affect)-208.8(reg-)]TJ
0 -1.2203 TD
[(ulation)-368.6(\(Brotman)-368.3(et)-367.1(al.,)-369.3(2010;)-361.4(Passarotti)-371.4(et)-367.1(al.,)-363(2010b,)-365.8(2010c,)]TJ
T*
[(2011;)-405.6(Pavuluri)-410.4(et)-405(al.,)-407.2(2008\).)-406.1(Therefore,)-412(this)-407(component)-409.2(was)]TJ
T*
[(labeled)-570.2(the)-566.5()55(Affect)-566.6(Evaluation)-567.9(and)-568.6(Regulation)-566.9(Network)51.5()]TJ
0 -1.2266 TD
[(\(Fig.)-211.8(3\).)-205.2(The)-208.6(regions)-212(presenting)-208(with)-211.4(group)-206.6(differences)-214.2(had)-208.2(in-)]TJ
0 -1.2203 TD
[(creased)-376.7(engagement)-379.6(during)-370.5(the)-376.8(task)-372.4(in)-373.6(the)-370.5(overall)-377.4(network)]TJ
T*
[(map,)-235.3(unless)-238.4(otherwise)-241.2(indicated.)-233.5(In)-233.1(line)-238(with)-236.6(our)-232.5(hypotheses,)]TJ
0 -1.2266 TD
(two-sample)Tj
/F5 1 Tf
5.4061 0 TD
(t)Tj
/F4 1 Tf
.3288 0 TD
[(-tests)-250.5(carried)-253.2(out)-251.2(in)-253.5(SPM5)-251.1(to)-256.2(examine)-252.5(group)-250.9(dif-)]TJ
-5.7349 -1.2203 TD
[(ferences)-226.2(\(with)-218.1(AlphaSim)-223.7(corrected)]TJ
/F5 1 Tf
15.194 0 TD
(p)Tj
/F6 1 Tf
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(<)Tj
/F4 1 Tf
.7145 0 TD
[(0.02\))-223.2(revealed)-215.8(that)-225.1(dur-)]TJ
-16.5787 -1.2203 TD
[(ing)-371.7(the)-370.5(task)-366.1(relative)-368.7(to)-370(HC,)-369.8(the)-370.5(PBD)-366.2(group)-371(showed)-366.1(greater)]TJ
0 -1.2266 TD
[(connectivity)-236.2(in)-228.2(this)-236.3(network)-228.3(in)-228.2(right)-233.8(dorsal)-232.1(ACC)-229.4(and)-227.2(bilateral)]TJ
0 -1.2203 TD
[(medial)-367.5(PFC,)-356.6(and)-366.3(lesser)-360.7(connectivity)-368.9(in)-361(right)-366.6(VLPFC,)-362.4(amyg-)]TJ
T*
[(dala,)-293(fusiform)-292.7(gyrus,)-287(putamen,)-291(posterior)-291.7(cingulate)-293.6(gyrus,)-287(bi-)]TJ
T*
[(lateral)-392.9(insula,)-388.6(inferior)-388(parietal)-394.2(lobule,)-385.2(and)-391.6(STS)-385.7(\(See)-390.8(Table)-389.7(5)]TJ
ET
62.022 689.556 239.131 .28345 re
f
62.022 570.274 239.131 .22675 re
f
62.022 670.62 239.131 .22675 re
f
62.022 608.995 239.131 .22681 re
f
BT
/F8 1 Tf
8.9663 0 0 8.9663 81.411 726.1227 Tm
(Table)Tj
/F4 1 Tf
3.0287 0 TD
(2.)Tj
/F8 1 Tf
1.2519 0 TD
[(Median)-303.1(Response)-301(Time)-301.2(and)-300.1(Accuracy)]TJ
-3.035 -1.1065 TD
[(for)-302.8(the)-300.4(Two-Back)-302.2(Working)-302.5(Memory)-298.1(Task)]TJ
-.9042 -1.1128 TD
[(in)-297.2(Patients)-306.3(with)-299.8(Pediatric)-298.3(Bipolar)-300.7(Disorder)]TJ
4.5715 -1.1128 TD
[(and)-306.4(in)-297.2(Healthy)-300.4(Controls)]TJ
/F5 1 Tf
5.4187 -2.1561 TD
[(PBD)-336.2(\()]TJ
/F4 1 Tf
2.6367 0 TD
(n)Tj
/F6 1 Tf
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/F5 1 Tf
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[(41\))-3502.4(HC)-334.4(\()]TJ
/F4 1 Tf
6.9173 0 TD
(n)Tj
/F6 1 Tf
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(=)Tj
/F5 1 Tf
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(16\))Tj
/F4 1 Tf
-24.9629 -2.0929 TD
[(Median)-336.9(RT)-329.7(\(in)-336.2(ms\))-3963.8(Median)-336.9(\(SD\))-3010.5(Median)-336.9(\(SD\))]TJ
0 -1.1128 TD
[(Angry)-336.8(face)-334.3(emotion)-4632.4(948)-333.6(\(163\))-4419.2(817)-333.7(\(130\))]TJ
T*
[(Neutral)-334.2(face)-340.6(emotion)-3589.2(1016)-333.2(\(268\))-4419.2(768)-333.7(\(161\))]TJ
0 -1.1065 TD
[(Total)-338.1(average)]TJ
6.7246 0 0 5.9768 115.9937 632.2392 Tm
(a)Tj
8.9663 0 0 8.9663 182.7212 628.2707 Tm
[(982)-333.6(\(216\))-4419.2(793)-333.7(\(146\))]TJ
-13.4615 -1.448 TD
[(Accuracy)-302.4(\(%)-299.3(correct\))-4486.5(%)-336.7(\(SD\))-5546(%)-330.4(\(SD\))]TJ
0 -2.0929 TD
[(Angry)-336.8(face)-334.3(emotion)-5132(96)-334.1(\(3\))-5925(99)-327.8(\(2\))]TJ
0 -1.1128 TD
[(Neutral)-334.2(face)-340.6(emotion)-4588.2(96)-334.1(\(3\))-5925(98)-327.8(\(2\))]TJ
0 -1.1065 TD
[(Total)-338.1(average)]TJ
6.7246 0 0 5.9768 115.9937 580.592 Tm
(b)Tj
8.9663 0 0 8.9663 187.1999 576.6235 Tm
[(96)-334.1(\(3\))-5925(99)-327.8(\(2\))]TJ
5.9774 0 0 5.3127 70.9795 565.5117 Tm
(a)Tj
7.9702 0 0 7.9702 73.9842 561.94 Tm
[(Signicant)-288.4(group)-295.1(effect)-300(\()]TJ
/F5 1 Tf
11.0182 0 TD
(p)Tj
/F6 1 Tf
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/F4 1 Tf
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[(0.0005\))-292.5(for)-295.6(RT.)]TJ
5.9774 0 0 5.3127 70.9795 556.5542 Tm
(b)Tj
7.9702 0 0 7.9702 74.2677 552.9825 Tm
[(Signicant)-295.5(group)-295.1(effect)-292.9(\()]TJ
/F5 1 Tf
11.0182 0 TD
(p)Tj
/F6 1 Tf
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/F4 1 Tf
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[(0.02\))-296.7(for)-295.6(accuracy.)]TJ
-12.8108 -1.1239 TD
[(RT,)-301(response)-295.1(time.)]TJ
ET
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62.079 65.934 489.827 .22678 re
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239.754 152.22 167.244 .22676 re
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62.079 134.532 489.827 .22675 re
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BT
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/F8 1 Tf
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[(Regression)-299.8(Coefcient)-304.6(Mean)-301.7(and)-300.1(Standard)-301.1(Deviation)-302.8(for)]TJ
/F10 1 Tf
28.8009 0 TD
(b)Tj
/F8 1 Tf
.5501 0 TD
[(-Weights)-303.7(Representing)]TJ
-33.1573 -1.1065 TD
[(Task)-302.2(Association)-301.8(for)-302.8(Each)-298.2(Network)-302.7(in)-297.2(Pediatric)-304.6(Bipolar)-300.7(Disorder)-303.3(and)-300.1(Healthy)-300.4(Control)]TJ
/F5 1 Tf
16.6735 -2.1561 TD
[(Time)-335.8(course)-339.6(coefficient)-332.9(mean)-334.6(\(SD\))]TJ
-.0696 -2.0107 TD
[(PBD)-10098.8(HC)-7846(Significant)-334.9(effects)-340.1(\()]TJ
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/F5 1 Tf
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0 -1.1065 TD
[(Affective)-305.7(Working)-301.1(Memory)-9503.7(0.415)-329.8(\(0.75\))]TJ
/F11 1 Tf
32.0003 0 TD
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/F4 1 Tf
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[(0.055)-298.1(\(0.64\))-5712(Group)-333.7(\(0.042\))]TJ
-32.7716 -2.3648 TD
[(Affect)-337.1(Evaluation)-340.3(and)-328.4(Regulation)-5713.7(0.077)-329.8(\(0.49\))-6831.1(0.394)-329.8(\(0.80\))]TJ
43.4258 1.2519 TD
[(Group)-333.7(\(0.049\))]TJ
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T*
(Group)Tj
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[(emotion)-339.2(\(0.089\))]TJ
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[(Signicant)-295.5(effects)-296.5(are)-297.3(reported)10.2(.)]TJ
/F1 1 Tf
8.9663 0 0 8.9663 62.022 749.5368 Tm
(6)Tj
44.7283 0 TD
[(PASSAROTTI)-304.6(ET)-300.7(AL.)]TJ
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[(exhibited)-210(reduced)-209.5(engagement)-208.9(within)-205.6(the)-206.1(network)-209.3(during)-206.1(the)]TJ
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T*
[(arrow)-302.5(in)-304.1(Table)-301.2(5\).)]TJ
/F9 1 Tf
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[(Secondary)-299.3(analyses)]TJ
/F2 1 Tf
1.1128 -1.8336 TD
[(Differential)-542.6(functional)-541.1(connectivity)-535.2(of)-545.4(the)-537.2(Face)-538.8(Emotion)]TJ
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[(Processing)-323(Network)-329.5(for)-326.2(angry)-331(or)-322.7(neutral)-330.1(faces.)]TJ
/F4 1 Tf
21.7887 0 TD
[(To)-321.9(identify)]TJ
-21.7887 -1.2203 TD
[(correlations)-498.4(between)-496.5(regional)-492(engagement)-493.4(within)-496.5(the)-497(face)]TJ
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[(processing)-359.4(network)-354.7(and)-353.7(angry)-353.9(or)-357.6(neutral)-356.6(face)-353.2(blocks)-357.2(across)]TJ
0 -1.2203 TD
[(groups)-245.9(\(note)-247.3(that)-250.4(for)-244.2(this)-249(component,)-254.1(there)-244.6(was)-249.1(only)-248.1(a)-239.8(signif-)]TJ
T*
[(icant)-227.5(valence)-221.2(effect\),)-231.5(we)-222.8(carried)-227.9(out)]TJ
/F5 1 Tf
15.4848 0 TD
[(post)-227.6(hoc)]TJ
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