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Biomedical systems research - new perspectives opened by quantitative medical imaging.

journal contribution
posted on 20.08.2012, 00:00 by Andreas A. Linninger
Recent advances in quantitative imaging allow unprecedented views into cellular chemistry of whole organisms in vivo. These novel imaging modalities enable the quantitative investigation of spatio-temporal reaction and transport phenomena in the living animal or the human body. This article will highlight the significant role that rigorous systems engineering methods can play for interpreting the wealth of in-vivo measurements. A methodology to integrate medical imaging modalities with rigorous computational fluid dynamics entitled image-based computational fluid dynamics (iCFD) will be introduced. The quantitative analysis of biological systems with rigorous mathematical methods is expected to accelerate the introduction of novel drugs by providing a rational foundation for the systematic development of new medical therapies. Rigorous engineering methods not only advance biomedical research, but also aid the translation of laboratory research results into the bedside practice.

History

Publisher Statement

NOTICE: this is the author’s version of a work that was accepted for publication in Computers and Chemical Engineering. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Computers and Chemical Engineering, Vol 36, Issue , (10 January 2012). DOI: 10.1016/j.compchemeng.2011.07.010

Publisher

Elsevier

Language

en_US

issn

0098-1354

Issue date

01/01/2012