Androgen signaling and endocrine disruptors - J Steriod Biochem.pdf (186.88 kB)
Disruption of Androgen Receptor Signaling in Males by Environmental Chemicals
journal contributionposted on 2011-05-27, 00:00 authored by Doug C. Luccio-Camelo, Gail S. Prins
Androgen-disruptors are environmental chemicals that interfere with the biosynthesis, metabolism or action of endogenous androgens resulting in a deflection from normal male developmental programming and reproductive tract growth and function. Since male sexual differentiation is entirely androgen-dependent, it is highly susceptible to androgen-disruptors. Animal models and epidemiological evidence link exposure to androgen disrupting chemicals with reduced sperm counts, increased infertility, testicular dysgenesis syndrome, and testicular and prostate cancers. Further, there appears to be increased sensitivity to these agents during critical developmental windows when male differentiation is at its peak. A variety of in vitro and in silico approaches have been used to identify broad classes of androgen disrupting molecules that include organochlorinated pesticides, industrial chemicals, and plasticizers with capacity to ligand the androgen receptor. The vast majority of these synthetic molecules act as anti-androgens. This review will highlight the evidence for androgen disrupting chemicals that act through interference with the androgen receptor, discussing specific compounds for which there is documented in vivo evidence for male reproductive tract perturbations.
Publisher StatementNOTICE: this is the author’s version of a work that was accepted for publication in Journal of Steroid Biochemistry and Molecular Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Steroid Biochemistry and Molecular Biology, [(April 13, 2011)] DOI: 10.1016/j.jsbmb.2011.04.004. The original publication is available at www.elsevier.com. Also link to journal’s home page.