University of Illinois at Chicago
NARVEKAR-THESIS-2020.pdf (1.54 MB)
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Biological Assessment of Used Dental Implant Healing Abutments

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posted on 2020-05-01, 00:00 authored by Aniruddh Narvekar
Objective: To determine if healing abutments (HA) can be truly “decontaminated” and to evaluate 4 decontamination strategies, available in most clinical settings, to determine the extent to which biomaterial can be removed compared to new unused HA. Methods: Forty HA were collected from subjects with prior implant placement were randomly distributed and detoxified using four protocols (A-D, N=10/group). Residual protein quantification (N=3/group) and macroscopic debris evaluation (N=2/group) was assessed. Human primary monocyte-derived macrophages (Mφ) were challenged with HA (N=5/group) and supernatants were collected at 4, 24, 48 and 120 h to analyze secretion of cytokines/chemokines. Results: Our study showed test groups (A-D) were not able to be “decontaminated” to levels of new, unused HA. A multiplex analyte assay performed on “decontaminated” test groups (A-D) revealed high levels of cytokine and chemokine secretion. HA should not be re-used due to the potential to initiate an inflammatory response, even after “decontamination” procedures are utilized.



Nares, Salvador


Nares, Salvador



Degree Grantor

University of Illinois at Chicago

Degree Level

  • Masters

Degree name

MS, Master of Science

Committee Member

Naqvi, Afsar Tozum, Tolga Ashrafi, Seema Yuan, Judy

Submitted date

May 2020

Thesis type



  • en

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